基于气血理论探究巨噬细胞极化在心肌缺血再灌注损伤中的作用  

Exploring the role of macrophage polarization in myocardial ischemia reperfusion injury based on the theory of Qi and blood

作　　者：李鹏[1] 李宇轩 李星星 张园园 逯金金[1] 崔晓云[1] 林谦[2] 李岩[1] LI Peng;LI Yu-xuan;LI Xing-xing;ZHANG Yuan-yuan;LU Jin-jin;CUI Xiao-yun;LIN Qian;LI Yan(Department of Cardiology,Dongfang Hospital,Beijing University of Chinese Medicine,Beijing 100078,China;Department of Cardiology,Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100027)

机构地区：[1]北京中医药大学东方医院心内科,北京100078 [2]北京中医药大学东直门医院心内科,北京100007

出　　处：《北京中医药》2023年第10期1120-1122,共3页Beijing Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(81973622);首都卫生发展科研专项(2020-2-4201)。

摘　　要：心肌缺血再灌注损伤(MIRI)是一种严重危害人类健康的疾病,中医学认为MIRI以气虚为本、血瘀为标,治疗需针对气虚血瘀进行调理。巨噬细胞极化状态在MIRI炎症中起抗炎和促炎的双向调节作用,与气血的调控内涵相似。基于二者的相关性,通过研究巨噬细胞的极化,探讨气血理论与MIRI之间的关系,发现气血理论对MIRI的治疗具有科学性和有效性。Myocardial ischemia-reperfusion injury(MIRI)is a condition that poses a significant threat to human well-being.In TCM,MIRI is believed to be rooted in Qi deficiency and characterized by blood stasis.Thus,achieving favorable outcomes requires regulating and treating both Qi deficiency and blood stasis.The polarization state of macrophages in MIRI inflammation exhibits a bidirectional regulation,namely,anti-inflammatory and pro-inflammatory responses,akin to the regulatory implications of Qi and Blood.Based on their correlation,investigating the polarization of macrophages serves to substantiate the relationship between the theory of Qi and blood and MIRI,leading to the identification of the scientific and effective aspects of Qi and blood theory in the treatment of MIRI.

关 键 词：气血理论 巨噬细胞极化 心肌缺血再灌注损伤 炎症反应 

分 类 号：R259[医药卫生—中西医结合]