基于网络药理学的积雪草酸治疗IA1期宫颈癌治疗机制的研究  

The Mechanistic of Asiatic Acid in the Treatment of Stage Ia1 Cervical Cancer Based on Network Pharmacology

作　　者：张军丹 秦海霞[1] 张运峰[2] 李华伟 ZHANG Jun-dan;QIN Hai-xia;ZHANG Yun-feng;LI Hua-wei(Obstetrics and Gynecology Department,First Affiliated Hospital of Xinxiang Medical College,Xinxiang 453100,China;Faculty of Life Science,Tangshan Normal University,Tangshan 063000,China;Research Office,Tangshan Normal University,Tangshan 063000,China)

机构地区：[1]新乡医学院第一附属医院妇产科,河南新乡453100 [2]唐山师范学院生命科学系,河北唐山063000 [3]唐山师范学院科研处,河北唐山063000

出　　处：《唐山师范学院学报》2023年第6期60-64,共5页Journal of Tangshan Normal University

基　　金：河南省高等学校重点科研项目计划(19A320030);河南省医学科技攻关计划项目(201602157);河北省高等学校科学技术研究项目(ZD2019302);唐山师范学院博士基金(2019A11)。

摘　　要：通过网络药理学方法筛选获得积雪草酸与IA1期宫颈癌的交集靶点,分析GO功能和信号通路,经拓扑学筛选核心靶点,进行分子对接验证。结果表明,积雪草酸与IA1期宫颈癌有60个交集靶点,涉及101项GO功能和30条KEGG信号通路,确定了4个核心靶点(IL1B、CXCL8、CCL2和TLR4),分子对接验证结果显示积雪草酸与核心靶点结合稳定。The intersection targets of asiatic acid and IA1 stage cervical cancer were screened through network pharmacology methods,GO function and signaling pathways were analyzed,and the core targets were screened through topology for molecular docking verification.The results showed that there were 60 intersecting targets between asiatic acid and stage IA1 cervical cancer,involving 101 GO functions and 30 KEGG signaling pathways.Four core targets(IL1B,CXCL8,CCL2,and TLR4)were identified,and molecular docking verification results showed stable binding between asiatic acid and the core targets.

关 键 词：积雪草酸 宫颈癌 网络药理学 核心靶点 

分 类 号：R711[医药卫生—妇产科学]