鸡马立克氏病抗性机制及抗病品系研究进展  

Advancements in Research on Marek's Disease Resistance and Breeding of Resistant Strains

作　　者：郑钢 杨玉琴 杜玉双 连玲[1] Zheng Gang;Yang Yuqin;Du Yushuang;Lian Ling(Department of Animal Genetics and Breeding,College of Animal Science and Technology,China Agricultural University,Beijing,100193)

机构地区：[1]中国农业大学动物科技学院,动物遗传资源与分子育种实验室,北京100193

出　　处：《中国畜禽种业》2023年第12期73-87,共15页The Chinese Livestock and Poultry Breeding

基　　金：自然科学基金(32272865和U1901206);国家重点研发项目(2022YFF1000204和2021YFD1300600);国家蛋鸡产业技术体系(CARS--40);家养动物种质资源库。

摘　　要：鸡马立克氏病(Marek's disease,MD)是淋巴细胞增生性肿瘤疾病,是危害家禽业的重要疫病。该文系统综述了不同MHC血清单倍型与MD的抗性关系;与MD有关的遗传标记,包括微卫星标记、单核苷酸多态性(SNP)位点、拷贝数变异区域(CNVR)、数量性状基因座(QTL);MDV感染过程中宿主基因与病毒基因的互作,包括抗性候选基因和非编码RNA在内的MD抗性遗传因子鉴定;抗性品系的培育,包括美国农业部禽病研究室培育的MD抗性品系和易感品系、海兰公司培育的HL-W36抗病品系、俄罗斯培育抗MD雪白鸡,国内培育的抗MD霞烟鸡以及含有特定MHC单倍型的群体等内容,以期为深入了解鸡马立克氏病抗性的遗传基础及抗病品系的培育提供参考。Marek's disease(MD)is a lymphoproliferative tumor disease,which is an important disease that endangers the poultry industry.This article systematically reviews the relationship between different MHC blood list ploidy and MD resistance.Genetic markers related to MD,including microsatellite markers,single nucleotide polymorphism(SNP)loci,copy number variation region(CNVR),quantitative trait loci(QTL);the interaction between host genes and viral genes during MDV infection,and the identification of MD resistance genetic factors including resistance candidate genes and non-coding RNAs;the cultivation of resistant strains include MD resistant strains and susceptible strains cultivated by the Poultry Disease Research Laboratory of the United States Department of Agriculture,HL-W36 disease-resistant strains cultivated by Hyline,MD snow white chickens cultivated in Russia,MD Xiayan chickens cultivated in China,and populations containing specific MHC haplotypes,etc.,to provide a reference for in-depth understanding of the genetic basis of chicken Marek's disease resistance and the cultivation of disease-resistant strains.

关 键 词：鸡马立克氏病 MHC 单倍型 遗传标记 基因表达调控 抗性系培育 

分 类 号：S858.31[农业科学—临床兽医学]