具有定向微孔结构的丝素蛋白导管用于周围神经损伤修复研究与应用进展  

Research and Application Progress of Silk Fibroin Conduits with Directional Micropore Structure for Peripheral Nerve Injury Repair

作　　者：万红霞 毛小晓 江津津[1] 王欢[1] 陈庆 WAN Hong-xia;MAO Xiao-xiao;JIANG Jin-jin;WANG Huan;CHEN Qing(School of Food Science and Health Preserving,Guangzhou City Polytechnic,Guangzhou 510405,China)

机构地区：[1]广州城市职业学院食品科学与美食养生学院,广东广州510405

出　　处：《广州城市职业学院学报》2023年第4期91-96,共6页Journal Of Guangzhou City Polytechnic

基　　金：广州城市职业学院校级科研项目“丝素蛋白⁃聚乳酸复合膜负载PRP对神经干细胞形态及分化的调控”(编号:KYY202113)。

摘　　要：丝素蛋白是一种从家养蚕丝中提取的天然生物材料,具有良好的物理化学性能、机械性能和降解性能,且提取方便,廉价安全,在药物控制支架和组织工程中得到广泛的应用。在周围神经损伤后再生修复与功能重建中,神经导管具有不受伦理限制、有效促进神经轴突再生的特点。应用定向冷冻技术制备丝素蛋白神经导管可以有效促进神经细胞黏附和轴突定向生长。文章对近年丝素蛋白联合定向冷冻技术构建神经导管修复受损周围神经的研究进展进行分析和综述,指出潜在的不足并对丝素蛋白神经导管的未来临床应用进行展望。Sericin protein,a natural biomaterial extracted from domestic silk,has good physicochemical,mechanical,and degradation properties,and is easy,cheap,and safe to extract,and has been widely used in drug⁃controlled scaffolds and tissue engineering.In the process of regenerative repair and functional reconstruction after peripheral nerve injury,nerve conduits have the characteristics of being free from ethical restrictions and effectively promoting nerve axon regeneration.The application of freeze⁃drying technology to prepare nerve conduit based⁃on silk fibroin can effectively promote the adhesion of nerve cells and the directional growth of axons.In this paper,the recent research progress of silk fibroin combined with freeze⁃drying technology to construct nerve conduit for repairing peripheral nerve injury was analyzed and reviewed,the potential shortcomings were pointed out and the future clinical application of fibroin nerve catheter was also prospected.

关 键 词：神经导管 外周神经损伤 丝素蛋白 定向冷冻技术 

分 类 号：R318[医药卫生—生物医学工程]