不同精液质量男性生殖激素水平与氧化应激的临床分析  

Clinical Analysis of Male Reproductive Hormone Levels and Oxidative Stress in Different Semen Quality

作　　者：曲莉[1] 于金凤 邓卓朋 李梓华 马佳羽 刘家铭 李环[1] 王洪艳[1] QU Li;YU Jinfeng;DENG Zhuopeng;LI Zihua;MA Jiayu;LIU Jiaming;LI Huan;WANG Hongyan(School of public Health,Beihua University,Jilin City,Jilin Province 132013,China)

机构地区：[1]北华大学公共卫生学院,吉林吉林132013

出　　处：《吉林医药学院学报》2024年第1期29-32,共4页Journal of Jilin Medical University

基　　金：国家级大学生创新创业训练计划(202110201033);吉林省教育厅科研基金资助课题(JJKH20200075KJ)。

摘　　要：目的分析不同精液质量男性生殖激素和抗氧化水平,探讨生殖激素及抗氧化对男性精液质量的影响。方法在北华大学附属医院生殖中心筛选28名单纯少精子症、36名单纯弱精子组和28名少弱精子症患者精液。精液分析按照世界卫生组织的标准进行。化学发光免疫法测定血清促卵泡生成素(FSH)、促黄体生成素、泌乳素、雌二醇、睾酮(T)浓度。黄嘌呤氧化酶法检测超氧化物歧化酶(SOD)活性,采用活性氧试剂盒检测精浆中活性氧(ROS)水平。结果不育组男性精液浓度、前向运动精子率、精子总活力和精子不活动率与对照组差异有统计学意义(P<0.05)。不育组患者血清中T浓度明显低于对照组,差异有统计学意义(P<0.05);少弱精症组中FSH明显高于对照组,差异有统计学意义(P<0.05)。不育组SOD活力和ROS水平与对照组相比差异有统计学意义(P<0.05)。结论睾酮合成下降与男性不育有关,少精、弱精、少弱精的重要原因可能是氧化应激中抗氧化剂与ROS的脂质过氧化损伤的不平衡。Objective Male reproductive hormones and antioxidant levels of different semen quality were analyzed to explore the effects of reproductive hormones and antioxidant on male semen quality.Methods In the reproductive center of Beihua University Hospital:28 oli-gospermia,36 oligosperm group and 28 patients.Semen analysis was performed according to the World Health Organization standards.Se-rum concentrations of follicle-stimulating hormone(FSH),luteinizing hormone,prolactin,estradiol,and testosterone(T)were deter-mined by chemiluminescence immunoassay.Results Semen concentration,forward motility sperm rate,total sperm motility and sperm immotility rate were significantly different in the control group(P<0.05).The serum T concentration of patients in the infertile group was significantly lower than that of the control group,statistically significant(P<0.05),and FSH in the group was significantly higher than that of the control group.The difference was statistically significant(P<0.05).SOD viability and ROS levels were significantly in the infer-tile group compared with the control group(P<0.05).Conclusion The decline in testosterone synthesis is not related to men,and the im-balance of lipid peroxidative damage between antioxidants and ROS in oxidative stress may be an important reason for less,weak and weak sperm.

关 键 词：精液质量 氧化应激 血清生殖激素 精浆 

分 类 号：R698.2[医药卫生—泌尿科学]