重组牛碱性成纤维细胞生长因子联合点阵CO_(2)激光对玫瑰痤疮皮损改善及皮肤屏障功能的影响  

Effect of Recombinant Bovine Basic Fibroblast Growth Factor Combined with Fractional CO_(2) Laser on Skin Lesions and Skin Barrier Function in Rosacea

作　　者：李燃 何启敏 熊玲玲 赵菊花 LI Ran;HE Qimin;XIONG Lingling;ZHAO Juhua(Department of Dermatology,Nanchong Central Hospital,Nanchong 637000,Sichuan,China)

机构地区：[1]南充市中心医院皮肤科,四川南充637000

出　　处：《中国美容医学》2023年第12期119-122,共4页Chinese Journal of Aesthetic Medicine

基　　金：四川省中医药管理局科学技术研究专项课题(编号:2020LC0419)。

摘　　要：目的:探讨重组牛碱性成纤维细胞生长因子联合点阵CO_(2)激光对玫瑰痤疮皮损及皮肤屏障功能的影响。方法:选取2020年1月-2020年12月于笔者医院就诊的玫瑰痤疮患者100例,随机分为对照组与观察组,各50例。对照组给予点阵CO_(2)激光治疗,观察组给予重组牛碱性成纤维细胞生长因子联合点阵CO_(2)激光治疗。观察两组患者治疗前与治疗1个疗程后毛细血管扩张、干燥、灼热、刺痛感严重程度、皮肤屏障功能变化,并记录治疗期间不良反应发生情况。结果:治疗前两组患者症状评分差异无统计学意义(P>0.05),治疗后各项症状评分均较治疗前下降,且观察组低于对照组(P<0.05);治疗前皮肤红斑指数(Erythemaindex,EI)、持久性红斑评分(Clinician's Erythema Assessment,CEA)两组间差异无统计学意义(P>0.05),治疗后EI、CEA均低于治疗前(P<0.05),且观察组低于对照组(P<0.05);治疗前两组患者油脂、表皮含水量、经皮水分丢失(TEWL)间差异无统计学意义(P>0.05),治疗后TEWL均低于治疗前(P<0.05),且观察组低于对照组(P<0.05),油脂、表皮含水量较治疗前升高(P<0.05),观察组高于对照组(P<0.05);观察组不良反应发生率4.00%低于对照组16.00%(P<0.05);观察组治疗总有效率82.00%,高于对照组的62.00%(P<0.05)。结论:重组牛碱性成纤维细胞生长因子联合点阵CO_(2)激光治疗玫瑰痤疮能进一步促进皮损及皮肤屏障功能改善,提高治疗疗效,且有助于降低不良反应发生率,值得临床推广使用。Objective To explore the effect of recombinant bovine basic fibroblast growth factor combined with fractional CO_(2) Laser on skin lesions and skin barrier function in rosacea.Methods One hundred patients with rosacea who attended the author's hospital from January 2020 to December 2020 were selected and randomly divided into a control group and an observation group of 50 cases each.The control group received fractional CO_(2) laser therapy,and the observation group received recombinant bovine basic fibroblast growth factor combined with fractional CO_(2) laser therapy.After 1 treatments,the severity of telangiectasia,dryness,burning,and tingling sensation,the skin barrier function were observed before and after treatment in the two groups,and the occurrence of adverse reactions during treatment.Results There was no significant difference in score for telangiectasia,dryness,burning,and tingling sensation between the two groups at before treatment(P>0.05),after treatment was lower than before treatment(P<0.05),and the observation group was lower than that control group(P<0.05).There was no significant difference in the severity scores of Skin erythema index(EI)and Clinician erythema Assessment Scale(CEA)between the two groups at before treatment(P>0.05),EI and CEA scores decreased compared after treatment with before treatment(P<0.05),and the observation group was lower than that control group(P<0.05).There were no significant differences in oil,epidermal water content and transcdermal horizontal water flow(TEWL)between the two groups at before treatment(P>0.05),TEWL decreased compared after treatment with before treatment(P<0.05),and the observation group was lower than ontrol group(P<0.05).The oil and epidermal water content were increased compared with before treatment(P<0.05),and the observation group was lower than that control group(P<0.05).The incidence rate of adverse reactions in the observation group was 4.00%lower than that in the control group,which was 16.00%(P<0.05).The total effective rate of treatm

关 键 词：重组牛碱性成纤维细胞生长因子 点阵CO_(2)激光 玫瑰痤疮 皮损 

分 类 号：R758.73[医药卫生—皮肤病学与性病学]