N6-甲基腺苷修饰与肿瘤相关巨噬细胞关系的研究进展  

Research advances in relationship between m^(6)A RNA methylation modification and tumor-associated macrophages

作　　者：姜符亮 黄岐伯 廖智斌 Jiang Fuliang;Huang Qibo;Liao Zhibin(Second Division of Clinical Medicine,Affiliated Tongji Hospital,Tongji Medical College,Huazhong University of Science&Technology,Hubei Wuhan 430030,China;Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases,Hubei Wuhan 430030,China;Department of Hepatic Surgery,Affiliated Tongji Hospital,Tongji Medical College,Huazhong University of Science&Technology,Hubei Wuhan 430030,China)

机构地区：[1]华中科技大学同济医学院附属同济医院第二临床学院,湖北武汉430030 [2]肝胆胰疾病湖北省重点实验室,湖北武汉430030 [3]华中科技大学同济医学院附属同济医院肝脏外科,湖北武汉430030

出　　处：《腹部外科》2023年第6期484-488,共5页Journal of Abdominal Surgery

基　　金：国家自然科学基金:(82103597)。

摘　　要：N6-甲基腺苷(N6-methyladenosine,m^(6)A)修饰被认为是真核细胞中最重要的表观遗传学调控之一。m^(6)A修饰在多种类型的肿瘤中,被学者们广泛研究。巨噬细胞作为先天免疫系统的吞噬细胞,发挥识别、吞噬、降解抗原和肿瘤细胞的作用。肿瘤相关巨噬细胞(tumor-associated macrophages,TMEs)在不同的肿瘤微环境中发挥着促癌或是抑癌的功能。近年来,已有很多文献报道m^(6)A修饰具有通过调控TMEs来调控肿瘤发生发展的能力。该文对m^(6)A甲基转移酶、去甲基化酶和甲基化识别蛋白的特征及m^(6)A相关蛋白对于TMEs在肿瘤中的作用机制进行了综述。针对m^(6)A修饰影响下TMEs的调控机制,提供了新的治疗靶点和研究思路。N6-methyladenosine(m^(6)A)is one of the most significant post-transcriptional modification in eukaryotics.The relationship between m^(6)A modification and abdominal tumors has become a hot-button issue.Macrophages are phagocytic cells of innate immune system serving vital functions in the recognition,phagocytosis and degradation of pathogens and tumor cells.Tumor-associated macrophages(TAMs)may switch the functions of suppressing or promoting tumor progression in diferent tumor microenvironments(TMEs).In recent years,many studies have demonstrated that m^(6)A modification could regulate tumor progression through regulating TAMs.This review summarized the characteristics of m A"writers","erasers"and"readers"and examined the relationship between m^(6)A and TAMs to provide new targets and research rationales for TAMs in m^(6)A modification.

关 键 词：N6-甲基腺苷 肿瘤免疫 肿瘤相关巨噬细胞 肿瘤微环境 

分 类 号：R392[医药卫生—免疫学]