Research Progress on the Influence of Structural Changes inμ-Conotoxins on Sodium Channel Receptors  

作　　者：Chengzhang LIN Yanling LIAO Jiao CHEN Bingmiao GAO 

机构地区：[1]Key Laboratory of Tropical Translational Medicine of Ministry of Education,School of Pharmacy,Hainan Medical University,Haikou 571199,China

出　　处：《Agricultural Biotechnology》2023年第6期99-105,共7页农业生物技术（英文版）

基　　金：Supported by Special Scientific Research Project of the Hainan Academician Innovation Platform,China(YSPTZX202132);Hainan Provincial Natural Science Foundation,China(820RC636);Hainan Provincial Key Point Research and Invention Program,China(ZDYF2022SHFZ309).

摘　　要：The voltage-gated sodium channel(Na v)is widely present in mammals and can generate cell action potentials,which are related to many diseases.Theμ-Conotoxins(μ-CTx)isolated from the venom of cone snails can specifically block the voltage-gated sodium channel;it can be widely used as a necessary probe to distinguish the Na v channel subtypes.In this study,the effects of eightμ-CTx on different Na v channel isoforms were reviewed,and sequence alignment and protein homologous modeling were used to predict their biological activities,and the structure-activity relationship betweenμ-CTx and mutagenesis strategies.

关 键 词：μ-Conotoxins voltage-gated sodium channel homologous modeling structure-activity relationship 

分 类 号：S814[农业科学—畜牧学]