尿毒清联合贝前列素治疗慢性肾小球肾炎的疗效及对患者肾功能的影响  

The Efficacy of Niaoduqing Combined with Beraprost in the Treatment of Chronic Glomerulonephritis and its Impact on Renal Function

作　　者：朱丽红 刘华梅 ZHU Lihong;LIU Huamei(Department of Pharmacy,Baoji Caijiapo Puan Hospital,Baoji Shaanxi 722400)

机构地区：[1]宝鸡蔡家坡普安医院药剂科,陕西宝鸡722400 [2]汉阴县人民医院肾内科,陕西安康725100

出　　处：《医学临床研究》2023年第11期1628-1630,1634,共4页Journal of Clinical Research

摘　　要：【目的】探讨尿毒清联合贝前列素治疗慢性肾小球肾炎(CGN)的疗效及对患者肾功能的影响。【方法】80例CGN患者,随机分为观察组和对照组,每组40例。在常规治疗干预下,对照组患者给予贝前列素治疗,观察组在此基础上另给予尿毒清治疗,均治疗90 d。比较两组临床疗效,治疗前后肾功能指标[24 h尿蛋白定量(24hUPro)、血肌酐(Scr)、尿素氮(BUN)、β2微球蛋白(β2-MG)]水平及炎症因子[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、超敏-C反应蛋白(hs-CRP)]水平,不良反应发生情况。【结果】观察组总有效率显著高于对照组(P<0.05)。治疗后,两组24hUPro、Scr、BUN、β2-MG及IL-6、TNF-α、hs-CRP水平较治疗前均下降(P<0.05),且观察组各指标水平显著低于对照组(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。【结论】尿毒清联合贝前列素治疗CGN疗效显著,能够有效改善患者肾功能,降低体内炎症因子水平,同时安全性较高,值得临床推广应用。【Objective】To investigate the efficacy of Niaoduqing combined with beraprost in the treatment of chronic glomerulonephritis(CGN)and its impact on patients'renal function.【Methods】A total of 80 patients with CGN were randomly divided into two groups,with 40 cases in each group.Under routine intervention,patients in the control group were treated with beraprost,while patients in the observation group were additionally treated with Uremic Clearance,with a course of treatment of 90 days.The clinical efficacy,renal function indicators[24 hour urinary protein quantitation(24hUPro),serum creatinine(Scr),blood urea nitrogen(BUN),β2-microglobulin(β2-MG)]levels,and inflammatory factors[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),high-sensitivity C-reactive protein(hs-CRP)]levels,as well as adverse reactions,were observed and compared between the two groups.【Results】The total effective rate in the observation group was significantly higher than that in the control group(P<0.05).After treatment,the levels of 24hUPro,Scr,BUN,β2-MG,IL-6,TNF-α,and hs-CRP in both groups decreased compared with those before treatment(P<0.05),and the levels of each index in the observation group were significantly lower than those in the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).【Conclusion】Niaoduqing combined with beraprost has significant efficacy in the treatment of CGN,which can effectively improve patients'renal function and reduce the level of inflammatory factors in the body.At the same time,it has high safety and is worthy of clinical application.

关 键 词：肾小球肾炎/中西医结合疗法 慢性病 依前列醇/类似物和衍生物 肾功能试验 

分 类 号：R692.31[医药卫生—泌尿科学]