不同剂量辛伐他汀对高脂血症患者血清sE-Selectin、sICAM-1水平的影响  

Effect of Simvastatin with Different Doses on Serum sE-Selectin and sICAM-1 Levels in Patients with Hyperlipidemia

作　　者：陈思文 陈亚绒 CHEN Siwen;CHEN Yarong(Department of Neurology,Tongchuan City People's Hospital,Tongchuan Shaanxi 727031)

机构地区：[1]铜川市人民医院神经内科,陕西铜川727031 [2]武功县人民医院神经内科,陕西咸阳712200

出　　处：《医学临床研究》2023年第11期1667-1669,共3页Journal of Clinical Research

摘　　要：【目的】探讨不同剂量辛伐他汀对高脂血症患者血清可溶性E-选择素(sE-Selectin)、可溶性细胞间黏附分子-1(sICAM-1)水平的影响。【方法】80例高脂血症患者,依据辛伐他汀使用剂量不同分为两组,每组40例。对照组给予常规剂量(20 mg/d)治疗,观察组给予高剂量(40 mg/d)治疗。比较两组患者临床疗效、不良反应发生率及治疗前后血脂指标[总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)],血清sE-Selectin、sICAM-1水平。【结果】观察组总有效率为92.50%(37/40),高于对照组的75.00%(30/40),且差异有统计学意义(P<0.05)。治疗后,两组患者TG、TC、LDL-C水平均低于治疗前,HDL-C水平高于治疗前(P<0.05),且观察组TG、TC、LDL-C水平低于对照组,HDL-C水平高于对照组(P<0.05)。两组治疗后血清sE-Selectin、sICAM-1水平均低于同组治疗前(P<0.05),且观察组各指标水平显著低于对照组(P<0.05)。两组患者不良反应总发生率比较,差异无统计学意义(P>0.05)。【结论】相较于常规剂量,给予高剂量辛伐他汀治疗高脂血症患者,疗效显著,降血脂效果更好。【Objective】To explore the effects of different doses of simvastatin on the levels of soluble E-selectin(sE-Selectin)and soluble intercellular adhesion molecule-1(sICAM-1)in the serum of patients with hyperlipidemia.【Methods】A total of 80 patients with hyperlipidemia were divided into two groups based on differently used dosage of simvastatin with each group of 40 patients.The control group was given a conventional dose(20 mg/d),while the observation group received a high dose(40 mg/d)treatment.The clinical efficacy,lipid profiles[total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),and low-density lipoprotein cholesterol(LDL-C)],serum levels of sE-Selectin and sICAM-1,and the incidence of adverse reactions were compared between the two groups.【Results】The total effective rate in the observation group was 92.50%(37/40),which was significantly higher than the 75.00%(30/40)in the control group(P<0.05).After treatment,the TG,TC,LDL-C levels of both groups were lower than before treatment,and HDL-C levels were higher than before treatment(P<0.05).Furthermore,the TG,TC,and LDL-C levels in the observation group were lower,and the HDL-C levels were higher than those in the control group(P<0.05).After treatment,the serum sE-Selectin and sICAM-1 levels in both groups were lower than before treatment(P<0.05),with the levels in the observation group being significantly lower than those in the control group(P<0.05).The overall incidence of adverse reactions in both groups showed no significant difference(P>0.05).【Conclusion】Compared to the conventional dosage,the high dose of simvastatin treatment for hyperlipidemia has a more remarkable therapeutic effect and better lipid-lowering results.

关 键 词：高脂血症 羟甲基戊二酰基COA还原酶抑制剂 胞间黏附分子1/血液 

分 类 号：R589.21[医药卫生—内分泌]