中医药治疗慢性胃炎伴焦虑或抑郁的Meta分析  

Meta-Analysis of traditional Chinese medicine in the treatment of chronic gastritis with anxiety or depress

作　　者：邢博宇 王垂杰[2] 李玉锋[2] XING Bo-yu;WANG Chui-jie;LI Yu-feng(Liaoning University of Traditional Chinese Medicine(TCM),Shenyang 110000,China)

机构地区：[1]辽宁中医药大学,沈阳110000 [2]辽宁中医药大学附属医院,沈阳110000

出　　处：《中国处方药》2023年第12期23-28,共6页Journal of China Prescription Drug

基　　金：第五批全国中医临床优秀人才研修项目(国中医药人教函[2022]1号)。

摘　　要：目的系统评价中医药治疗慢性胃炎(CG)伴焦虑、抑郁的临床疗效及安全性。方法检索中国知网、维普资讯、万方数据库、中国生物医学文献数据库、PubMed、Embase中有关CG伴焦虑、抑郁的临床随机对照研究,检索时间均从建库至2022年12月,由2名研究员对文献进行筛选、资料提取、根据“Cochrane偏倚风险评估工具”进行文献评价,使用“RevMan5.4”软件进行数据分析。结果最终纳入随机对照研究共9项目,共计724名CG伴焦虑、抑郁受试者。Meta分析结果显示:中医药在改善CG伴焦虑、抑郁的临床有效率(RR=1.24,95%CI:1.16~1.33)、显效率(RR=1.47,95%CI:1.29~1.68)、临床症状总积分(SMD=-1.19,95%CI:-1.47~-0.91)、胃脘痛(SMD=-0.97,95%CI:-1.29~-0.66)、胁肋胀痛(SMD=-1.00,95%CI:-1.31~-0.68)优于单纯西药组;在治疗焦虑、抑郁方面,中医药治疗CG伴焦虑(SMD=-3.61,95%CI:-4.10~-3.11)、抑郁(SMD=-1.56,95%CI:-2.25~-0.88)明显优于单纯西医治疗,差异均具有统计学意义(P<0.05)。结论中医药治疗CG伴焦虑、抑郁疗效优且安全性高。但因纳入的文献质量等存在局限性,还需要更精确、更有价值的研究进一步验证。Objective To systematically evaluate the clinical efficacy and safety of traditional Chinese medicine in the treatment of chronic gastritis(CG)with anxiety or depress.Methods Clinical randomized controlled trial(RCT)on CG with anxiety or depress in CNKI,VIP,Wanfang,CBM,PubMed and Embase were retrieved from database inception to December 2022,and two researchers screened the literature,extracted the data,evaluated the literature according to the"Cochrane risk-of-bias tool”,and used the"RevMan5.4"for data analysis.Results A total of 9 randomized controlled trials involving a total of 724 subjects with CG and anxiety or depression were included.The results of meta-analysis showed that TCM had clinical efficacy(RR=1.24,95%CI:1.16~1.33),apparent efficiency(RR=1.47,95%CI:1.29~1.68),total clinical symptom score(SMD=-1.19,95%CI:-1.47~-0.91),stomach pain(SMD=-0.97,95%CI:-1.29~-0.66),flank swelling pain(SMD=-1.00,95%CI:-1.31~-0.68)was better than the western medicine group;In the treatment of anxiety and depression,the treatment of CG with anxiety(SMD=-3.61,95%CI:-4.10~-3.11)or depress(SMD=-1.56,95%CI:-2.25~-0.88)in the treatment of CG with anxiety or depress was significantly better than western medicine alone,and the differences were statistically significant(P<0.05).Conclusion TCM has excellent efficacy and high safety in the treatment of CG with anxiety or depress.However,due to limitations in the quality of the included literature,more precise and valuable studies are needed for further verification.

关 键 词：慢性胃炎 焦虑 抑郁 中医药 META分析 

分 类 号：R259[医药卫生—中西医结合] R277.7[医药卫生—中医内科学]