荷丹片治疗冠心病临床随机对照试验的Meta分析  

Meta-analysis of clinical randomized controlled trials of Hedan Tablets in the treatment of coronary heart disease

作　　者：南瑞雪 陈勇 何德英[2] 王毅刚[2] 任毅[2] NAN Rui-xue;CHEN Yong;HE De-ying(Chengdu University of Traditional Chinese Medicine,Chengdu 610032,China)

机构地区：[1]成都中医药大学,成都610032 [2]重庆市中医院,重庆400021

出　　处：《中国处方药》2023年第12期34-38,共5页Journal of China Prescription Drug

基　　金：重庆市科卫联合中医药技术创新与应用发展项目(2020ZY023938);重庆市自然科学基金重点项目(cstc2021ycjh-bgzxm0045)。

摘　　要：目的系统评价荷丹片治疗冠心病的有效性及安全性。方法两名研究者系统检索荷丹片治疗冠心病的文献,包括中国知网、中国学术期刊数据库(CSPD)、万方数据库、维普中文科技期刊全文数据库(VIP)、中文科技期刊数据库(CCD)、The Cochrane Library、PubMed数据库中有关荷丹片治疗冠心病的临床随机对照试验,两名研究者独立地整理文献并评价文献质量,检索时间为2022年9月前。结果共纳入9项符合要求研究,纳入研究涉及837例患者。Meta分析结果显示治疗前后的有效性、血脂水平及炎性因子水平治疗组均优于对照组,有1项研究提及了不良反应。结论荷丹片治疗冠心病患者的临床疗效优于常规治疗组。荷丹片可以降低冠心病患者的血脂水平,对冠心病患者的TNF-a、IL-6、hs-CRP等炎性因子指标都有调节作用。Objective To systematically evaluate the efficacy and safety of Hedan Tablets in the treatment of coronary heart disease.Methods Two researchers systematically searched the literature on the treatment of coronary heart disease with Hedan Tablets,clinical randomized controlled trials on Hedan Tablets in the treatment of coronary heart disease were included in CNKI,China Academic Journal Database(CSPD),Wanfang Database,VIP Chinese Science and Technology Journal Full-text Database(CCD),the Cochrane Library,PubMed.Two researchers independently collated the literature and evaluated the quality of the literature.The retrieval time was before September 2022.Results A total of 9 eligible studies were included,involving 837 patients.Meta-analysis results showed that the efficacy,lipid levels and inflammatory factors before and after treatment were better in the treatment group than in the control group,and adverse reactions were mentioned in one study.Conclusion The clinical efficacy of Hedan Tablet in the treatment of coronary heart disease is better than that of conventional treatment group.Hedan Tablets can reduce the blood lipid level in patients with coronary heart disease,and regulate the inflammatory factors such as TNF-a,IL-6 and hs-CRP in patients with coronary heart disease.Hedan Tablet is effective in the treatment of coronary heart disease and can provide clinical treatment ideas.

关 键 词：荷丹片 冠心病 随机对照试验 META分析 

分 类 号：R285.6[医药卫生—中药学]