血糖调节和糖尿病干预的神经调控技术研究进展  

Research advances in neuromodulation techniques for blood glucose regulation and diabetes intervention

作　　者：刘洪运(综述)[1,2] 王卫东(审校) LIU Hongyun;WANG Weidong(Research Center for Biomedical Engineering,Medical Innovation&Research Division,Chinese PLA General Hospital,Beijing 100853,P.R.China;Key Laboratory of Biomedical Engineering and Translational Medicine,Ministry of Industry and Information Technology,Beijing 100853,P.R.China)

机构地区：[1]中国人民解放军总医院医学创新研究部生物工程研究中心,北京100853 [2]工业和信息化部生物医学工程与转化医学重点实验室,北京100853

出　　处：《生物医学工程学杂志》2023年第6期1227-1234,共8页Journal of Biomedical Engineering

基　　金：科技创新——2030“新一代人工智能”重大项目(2020AAA0105800)。

摘　　要：糖尿病及其并发症严重威胁着生命安全和人类健康,是全球关注的公共卫生问题。血糖控制是糖尿病干预和患者管理的关键。传统生活方式干预、药物、手术等疗法使不少患者受益。然而,由于患者依从性差、药物副作用、手术适应证局限等问题的存在,仍有患者难以有效控制血糖水平。随着生物电子医学的发展,神经调控技术以其特有的优势,在血糖控制和糖尿病干预领域展现了巨大的潜力。本文主要综述外周神经电刺激、超声神经调控、光遗传学等神经调控技术在血糖水平调节和糖尿病干预领域的研究进展和最新成果,分析存在的问题并展望发展趋势,以推动神经调控技术治疗糖尿病的临床研究及应用。Diabetes and its complications that seriously threaten the health and life of human,has become a public health problem of global concern.Glycemic control remains a major focus in the treatment and management of patients with diabetes.The traditional lifestyle interventions,drug therapies,and surgeries have benefited many patients with diabetes.However,due to problems such as poor patient compliance,drug side effects,and limited surgical indications,there are still patients who fail to effectively control their blood glucose levels.With the development of bioelectronic medicine,neuromodulation techniques have shown great potential in the field of glycemic control and diabetes intervention with its unique advantages.This paper mainly reviewed the research advances and latest achievements of neuromodulation technologies such as peripheral nerve electrical stimulation,ultrasound neuromodulation,and optogenetics in blood glucose regulation and diabetes intervention,analyzed the existing problems and presented prospects for the future development trend to promote clinical research and application of neuromodulation technologies in the treatment of diabetes.

关 键 词：糖尿病干预 神经调控 迷走神经刺激 超声神经调控 光遗传学 

分 类 号：R587.2[医药卫生—内分泌]