小剂量多巴胺联合多巴酚丁胺治疗小儿重症肺炎的效果  

Effect of Low-Dose Dopamine Combined With Dobutamine in the Treatment of Severe Pneumonia in Children

作　　者：瓦杨 舒秀锦 程耀 WA Yang;SHU Xiujin;CHENG Yao(Department of Pediatrics,Bijie Traditional Chinese Medicine Hospital,Guizhou Province,Bijie Guizhou 551700,China)

机构地区：[1]贵州省毕节市中医院儿内科,贵州毕节551700

出　　处：《中国卫生标准管理》2023年第24期125-129,共5页China Health Standard Management

摘　　要：目的分析在小儿重症肺炎的临床治疗中联合给予小剂量多巴胺与多巴酚丁胺的疗效。方法选取2021年5月—2023年5月贵州省毕节市中医院收治的68例重症肺炎患儿,通过数字表法进行分组抽签,对照组与观察组各34例。两组均开展常规治疗,基于此对照组患儿给予多巴酚丁胺治疗,观察组患儿联合给予小剂量多巴胺与多巴酚丁胺治疗。对两组临床治疗效果、临床指标、不良反应,治疗前后血气指标、炎症因子指标进行比较。结果观察组总有效率高于对照组,不良反应总发生率低于对照组(P<0.05);观察组呼吸恢复正常时间、心率恢复正常时间、发热消失时间、发绀消失时间、肺啰音消失时间、住院时间均短于对照组(P<0.05);治疗前,两组血气指标及炎症因子水平比较,差异无统计学意义(P>0.05);治疗后,观察组患儿血气指标中动脉血氧分压(pulmonary arterial oxygen tension,PaO_(2))、氧合指数(oxygenation index,OI)高于对照组,动脉二氧化碳分压(arterial carbon dioxide partial pressure,PaCO_(2))低于对照组(P<0.05);观察组炎症因子水平低于对照组(P<0.05)。结论在小儿重症肺炎的临床治疗中联合给药小剂量多巴胺与多巴酚丁胺可有效提升治疗有效性和安全性,对呼吸功能及炎症症状的改善方面具有重要作用,可促进其尽快康复。Objective To analyze the efficacy of combined administration of low-dose dopamine and dobutamine in the clinical treatment of pediatric severe pneumonia.Methods A total of 68 children with severe pneumonia admitted to Bijie Traditional Chinese Medicine Hospital,Guizhou Province from May 2021 to May 2023 were selected and divided into groups by number table method,with 34 cases in each control group and observation group..Both groups carried out conventional treatment,based on the control group children were given dobutamine treatment,and the children in the observation group were combined with low-dose dopamine and dobutamine treatment,and the clinical treatment effect,recovery indexes,adverse reactions,blood gas indexes and inflammatory factor indexes before and after treatment were compared for the clinical treatment effect,clinical indexes,adverse reactions of children between the groups.Results The total effective rate of the observation group was higher than that of the control group,and the total incidence of adverse reactions was lower than that of the control group(P<0.05).The time for respiration to normal,heart rate to normal,fever disappearance,cyanosis disappearance,pulmonary rales disappearance time and hospital stay in the observation group were shorter than those in the control group(P<0.05).There was no significant difference in blood gas indexes and inflammatory factor levels between the two groups before treatment(P>0.05),but after treatment,the pulmonary arterial oxygen tension(PaO_(2))and oxygenation index(OI)in the observation group were higher than those in the control group,and the arterial carbon dioxide partial pressure(PaCO_(2))were lower than those in the control group(P<0.05),and the level of inflammatory factors was lower than that in the control group(P<0.05).Conclusion The combination of low-dose dopamine and dobutamine in the clinical treatment of pediatric severe pneumonia can effectively improve the efficacy and safety of treatment,play an important role in improving respiratory

关 键 词：小儿重症肺炎 小剂量 多巴胺 多巴酚丁胺 血气分析 炎症因子 

分 类 号：R725[医药卫生—儿科]