半剂量^(18)F-FDG对婴幼儿全身PET/CT图像质量的影响  

Impact of half-dose ^(18)F-FDG on the image quality of total-body PET/CT in infants and toddlers

作　　者：陈琬琦 刘磊 樊卫[1] 胡莹莹[1] Chen Wanqi;Liu Lei;Fan Wei;Hu Yingying(Department of Nuclear Medicine,Sun Yat-Sen University Cancer Center,Guangzhou 510060,China)

机构地区：[1]中山大学肿瘤防治中心核医学科,广州510060

出　　处：《中华核医学与分子影像杂志》2023年第12期713-717,共5页Chinese Journal of Nuclear Medicine and Molecular Imaging

摘　　要：目的探讨在婴幼儿患者中,注射半剂量^(18)F-FDG对全身PET/CT图像质量的影响。方法回顾性分析2021年1月至2023年8月间在中山大学肿瘤防治中心行^(18)F-FDG全身PET/CT显像的婴幼儿共59例,其中按体质量注射全剂量^(18)F-FDG(3.70 MBq/kg)的患儿共21例[男11例、女10例;年龄22.0(7.5,34.5)个月],注射半剂量^(18)F-FDG(1.85 MBq/kg)的患儿共38例[男24例、女14例;年龄20.0(9.3,33.3)个月],均常规采集10 min。对2组分别进行图像质量评分,并测量2组患儿肝脏和纵隔血池的SUV及其标准差(SD)、信噪比(SNR)以及根据剂量时间标准化的SNR(SNRnorm)。采用Mann-WhitneyU检验比较不同测量参数在2组间的差异;采用Spearman秩相关分析年龄、体质量与图像质量的相关性。结果全剂量组^(18)F-FDG注射剂量为46.99(27.75,50.42)MBq,半剂量组^(18)F-FDG注射剂量为21.83(18.13,28.86)MBq。相比全剂量组,半剂量组纵隔血池SD稍高,2组间差异具有统计学意义[0.04(0.03,0.05)和0.05(0.04,0.08);z=-2.32,P=0.021];余SUV参数2组间差异均无统计学意义(z值:-1.92~-0.48,均P>0.05)。图像质量方面,全剂量组和半剂量组肝脏SNR分别为29.5(25.3,39.9)、25.8(22.0,30.4),2组间差异无统计学意义(z=1.66,P=0.096);2组纵隔血池SNR差异也无统计学意义[20.0(11.4,31.0)和19.0(11.4,31.0);z=0.02,P=0.981]。相关分析显示,SNRnorm随着年龄及体质量增加而减小(rs值:-0.704、-0.647,均P<0.001)。结论婴幼儿患者行半剂量^(18)F-FDG全身PET/CT显像10 min,图像质量仍然保持良好,图像质量随年龄及体质量增加呈下降趋势。Objective To explore the impact of half-dose ^(18)F-FDG on the image quality in infants and toddlers undergoing total-body PET/CT.Methods From January 2021 to August 2023,59 infants and toddlers undergoing total-body ^(18)F-FDG PET/CT scans at Sun Yat-Sen University Cancer Center were retrospectively enrolled.Of these,21 patients(11 males,10 females;age:22.0(7.5,34.5)months)were given a full dose of ^(18)F-FDG(3.70 MBq/kg),and the other 38 patients(24 males,14 females;age:20.0(9.3,33.3)months)received half dosage(1.85 MBq/kg)both with 10-minute scans.The differences of image quality scores and quantitative parameters including SUV,standard deviation(SD)of SUV,signal-to-noise ratio(SNR),and the normalized SNR for administered activity and scan time(SNRnorm)were compared between the two groups by Mann-Whitney U test.The correlations between age,body weight and image quality were analyzed by Spearman rank correlation analysis.Results The injected dosage of ^(18)F-FDG for the full-dose group was 46.99(27.75,50.42)MBq,while for the half-dose group was 21.83(18.13,28.86)MBq.Compared to the full-dose group,the half-dose group had higher SD in the mediastinal blood pool(0.04(0.03,0.05)vs 0.05(0.04,0.08);z=-2.32,P=0.021).No statistically significant differences were observed between the two groups in terms of other SUV parameters(z values:from-1.92 to-0.48,all P>0.05).In terms of image quality,the liver SNR of full-dose group was 29.5(25.3,39.9),while that of half-dose group was 25.8(22.0,30.4),with no significant difference(z=1.66,P=0.096).The SNR values of mediastinal blood pool showed the same comparing result(20.0(11.4,31.0)vs 19.0(11.4,31.0);z=0.02,P=0.981).The correlation analysis revealed that SNRnorm decreased with increasing age and body weight(rs values:-0.704,-0.647,both P<0.001).Conclusions In infants and toddlers,half-dose ^(18)F-FDG total-body PET/CT with 10-minute scan can still achieve good performance.There is an observed decline in image quality with increasing age and body weight.

关 键 词：肿瘤 婴儿 正电子发射断层显像术 体层摄影术 X线计算机 氟脱氧葡萄糖F18 低剂量 

分 类 号：R817.4[医药卫生—影像医学与核医学]