血液灌流联合连续性静脉-静脉血液滤过治疗对感染性休克患者血清乳酸、炎性因子水平及预后的影响  

Effect of hemoperfusion combined with continuous venous-venous hemofiltration therapy on the serum levels of lactate and inflammatory factor and prognosis in patients with infectious shock

作　　者：欧阳丽芬 罗丹 王龙海 何青云 康骏 OUYANG Lifen;LUO Dan;WANG Longhai;HE Qingyun;KANG Jun(Department of Critical Care Medicine,Jiangxi TCM-Integrated Hospital,Nanchang 330002,China)

机构地区：[1]江西省中西医结合医院重症医学科,南昌330002

出　　处：《上海医药》2023年第23期61-64,共4页Shanghai Medical & Pharmaceutical Journal

摘　　要：目的 :探讨血液灌流(hemoperfusion, HP)联合连续性静脉-静脉血液滤过(continuous venous-venous hemofiltration, CVVH)治疗对感染性休克患者血清乳酸、炎性因子水平及预后的影响。方法 :将100例感染性休克患者随机分为观察组(n=50)和对照组(n=50)。对照组采用CVVH治疗,观察组采用CVVH联合HP治疗。比较2组血清乳酸水平、炎性因子水平及预后情况。结果 :治疗后,观察组血清乳酸水平、炎性因子水平和病死率均低于对照组(均P <0.05)。结论:感染性休克患者采用CVVH联合HP治疗效果较好,利于降低血清乳酸水平,减轻机体炎性反应,改善患者预后。Objective:To investigate the effects of hemoperfusion(HP)combined with continuous venous-venous hemofiltration(CVVH)therapy on the serum levels of lactate and inflammatory factor and prognosis in patients with infectious shock.Methods:One hundred patients with infectious shock were randomly divided into an observation group(n=50)and a control group(n=50).The control group was treated with CVVH and the observation group was treated with CVVH combined with HP.The serum levels of lactate and inflammatory factorl and prognosis were compared between the two groups.Results:After treatment,the serum levels of lactate and inflammatory factor and the morbidity and mortality rates were lower in the observation group than the control group(all P<0.05).Conclusion:The combination therapy for the patients with infectious shock has better efficacy,can reduce the serum lactate level and the inflammatory reaction of the body and improve the prognosis of patients.

关 键 词：感染性休克 血液灌流 血液滤过 血清乳酸 炎性因子 预后 

分 类 号：R459.5[医药卫生—治疗学] R631.4[医药卫生—临床医学]