中药羊踯躅治疗类风湿关节炎的研究进展  

Research progress on Rhododendron molle in treatment of rheumatoid arthritis

作　　者：梅文亚 刘湘丹[1,2,3] 王志辉 于俊保[1] 何佳蔚 张惊宇 周日宝 刘笑蓉 MEI Wen-ya;LIU Xiang-dan;WANG Zhi-hui;YU Jun-bao;HE Jia-wei;ZHANG Jing-yu;ZHOU Ri-bao;LIU Xiao-rong(School of Pharmacy,Hunan University of Chinese Medicine,Changsha 410208,China;Key Research Laboratory of Germplasm Resources and Standardized Planting of Genuine Regional Medicinal Materials Produced in Hunan Province,Changsha 410208,China;Key Laboratory of Modern Research of Traditional Chinese Medicine,Education Department of Hunan Province,Changsha 410208,China)

机构地区：[1]湖南中医药大学药学院,湖南长沙410208 [2]湘产大宗道地药材种质资源及规范化种植重点研究室,湖南长沙410208 [3]湖南省普通高等学校中药现代化研究重点实验室,湖南长沙410208

出　　处：《中国中药杂志》2023年第21期5690-5700,共11页China Journal of Chinese Materia Medica

基　　金：湖南省自然科学基金项目(2022JJ80086,2023JJ60342);湖南省卫生健康委计划研究项目(D202302078705);湖南省教育厅科学研究项目(19C1384);湖南省大学生创新创业训练计划项目(2022-5313);湖南省中医药管理局科研计划项目(2021161);湖南中医药大学中药学一级学科开放基金项目(2020ZYX01);湖南中医药大学青苗计划项目(校行人字[2017]25);湖南省一流学科中药学项目(校行科字[2018]3);2020年湖南省一流本科专业建设点项目(湘教通[2020]248号);2020年国家级一流本科专业建设点项目(教高厅函[2021]7号)。

摘　　要：类风湿关节炎(RA)作为一种慢性自身免疫性疾病,发病率和致残率极高,给患者造成了极大痛苦,因发病机制复杂,至今尚未完全阐明,其治疗仍是医学界亟待攻破的难题,采用西药治疗虽具有一定疗效,需长期使用且价格昂贵,并存在多发感染、恶性肿瘤等不良反应。中药羊踯躅是我国一味传统民间药材,具有祛风除湿、镇静止痛等药理作用,民间常用于治疗风湿骨病顽疾,近年来,现代临床及药理学研究表明羊踯躅二萜类成分为羊踯躅中的有效成分,具有免疫调节、抗炎、镇痛等作用,可有效治疗RA,具有广泛的应用前景,但羊踯躅具有一定的毒性,严重阻碍了其临床推广应用,造成羊踯躅资源浪费。该文从化学成分、抗炎、镇痛等角度综述了近年来羊踯躅防治RA作用机制的研究进展,并总结了羊踯躅的不良反应,以期为寻找抗类风湿关节炎天然药物及中药羊踯躅减毒增效的方法提供新思路,明确羊踯躅及其提取物的安全性和有效性,为其应用前景提供一定理论依据,进一步加强羊踯躅资源的开发利用。Rheumatoid arthritis(RA),as a chronic autoimmune disease,has a high incidence and disability rate,causing significant suffering to patients.Due to its complex pathogenesis,it has not been fully elucidated to date,and its treatment remains a challenging problem in the medical field.Although western medicine treatment options have certain efficacy,they require prolonged use and are expensive.Additionally,they carry risks of multiple infections and adverse reactions like malignancies.The Chinese herbal medicine Rhododendron molle is commonly used in folk medicine for its properties of dispelling wind,removing dampness,calming nerves,and alleviating pain in the treatment of diseases like rheumatic bone diseases.In recent years,modern clinical and pharmacological studies have shown that the diterpenoids in R.molle are effective components,exhibiting immune-regulatory,anti-inflammatory,and analgesic effects.This makes it a promising candidate for treating RA with a broad range of potential applications.However,R.molle has certain toxic properties that hinder its clinical application and lead to the wastage of its resources.This study reviewed recent research progress on the mechanism of R.molle in preventing and treating RA,focusing on its chemical components,anti-inflammatory and analgesic properties and summarized the adverse reactions associated with R.molle,aiming to offer new ideas for finding natural remedies for RA and methods to reduce toxicity while enhancing the effectiveness of R.molle.The study seeks to clarify the safety and efficacy of R.molle and its extracts,providing a theoretical basis for its application prospects and further promoting the development and utilization of R.molle resources.

关 键 词：羊踯躅 类风湿关节炎 rhodojaponin-Ⅲ 二萜类化合物 作用机制 

分 类 号：R259[医药卫生—中西医结合]