天然愈创木烷型倍半萜类成分及其生物活性研究进展  

Research progress on natural guaiane-type sesquiterpenoids and their biological activities

作　　者：郭杰 王家平 彭博[1] 刘晓谦[1] 杨晨曦 闫利华[1] 王智民[1] GUO Jie;WANG Jia-ping;PENG Bo;LIU Xiao-qian;YANG Chen-xi;YAN Li-hua;WANG Zhi-min(Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China)

机构地区：[1]中国中医科学院中药研究所,北京100700

出　　处：《中国中药杂志》2023年第21期5727-5749,共23页China Journal of Chinese Materia Medica

基　　金：中国中医科学院科技创新工程项目(CI2021A04406,CI2023E001TS03);中央级公益性科研院所基本科研业务费专项(ZXKT23017);国家药典委员会标准制修订研究课题(2018Z079);国家中药标准化项目(ZYBZH-C-JL-24)。

摘　　要：愈创木烷型倍半萜是以3个异戊二烯单元构成4,10-二甲基-7-异丙基取代的[5,7]并环结构为基本母核的一类化合物。按照官能团差异及聚合度,可分为简单愈创木烷型、愈创木内酯型、二聚体及三聚体。天然来源的愈创木烷型倍半萜广泛分布于植物、真菌及海洋生物中,尤其常见于菊科、姜科、瑞香科、唇形科、泽泻科等植物中。该类化合物具有抗菌、抗炎、抗肿瘤、神经保护等多种生物活性。该文对近10年(2013—2022年)新分离鉴定的339个愈创木烷型倍半萜的化学结构及生物活性进行归纳总结,以期为愈创木烷型倍半萜类成分的深入研究和开发利用提供参考。Guaiane-type sesquiterpenoids are a class of terpenoids with [5,7] ring-fused system as the basic skeletal structure composed of three isoprene units,which are substituted by 4,10-dimethyl-7-isopropyl.According to the difference in functional groups and degree of polymerization,they can be divided into simple guaiane-type sesquiterpenoids,sesquiterpene lactones,sesquiterpene dimers,and sesquiterpene trimers.Natural guaiane-type sesquiterpenoids are widely distributed in plants,fungi,and marine organisms,especially in families such as Compositae,Zingiberaceae,Thymelaeaceae,Lamiaceae,and Alismataceae.Guaiane-type sesquiterpenoids have good antibacterial,anti-inflammatory,anticancer,and neuroprotective effects.In this paper,the novel guaiane-type sesquiterpenoids isolated and identified in recent 10 years(2013—2022) and their biological activities were reviewed in order to provide refe-rences for the research and development of guaiane-type sesquiterpenoids.

关 键 词：愈创木烷型倍半萜 抗菌活性 抗炎活性 抗肿瘤活性 神经保护活性 

分 类 号：R284.1[医药卫生—中药学]