道地药材“优形、优质”形成的微进化机制研究进展  

Research progress in microevolutionary process of excellent traits and quality of Dao-di herbs

作　　者：张成才 孙嘉惠 汪奕衡 王红阳 郭秀芝 闫滨滨 孙智 王升[1,2,3] 郭兰萍 ZHANG Cheng-cai;SUN Jia-hui;WANG Yi-heng;WANG Hong-yang;GUO Xiu-zhi;YAN Bin-bin;SUN Zhi;WANG Sheng;GUO Lan-ping(State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs,National Resource Center for Chinese Materia Medica,China Academy of Chinese Medical Sciences,Bejing 100700,China;Dexing Research and Training Center of Chinese Medical Sciences,Dexing 334213,China;Key Laboratory of Biology and Cultivation of Chinese Medicinal Materials,Ministry of Agriculture and Rural Affairs,Bejing 100700,China)

机构地区：[1]中国中医科学院中药资源中心,道地药材品质保障与资源持续利用全国重点实验室,北京100700 [2]德兴市中医研究院试验培训基地,江西德兴334213 [3]农业农村部中药材生物学与栽培重点实验室,北京100700

出　　处：《中国中药杂志》2023年第22期6021-6029,共9页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金重大项目(81891014);中国中医科学院科技创新工程项目(CI2021A03903,CI2021A03905,CI2021B013);财政部和农业农村部国家现代农业产业技术体系项目(CARS-21)。

摘　　要：道地药材是中药宝库中的精华,是最具中医药特色的研究对象之一。道地药材微进化研究有助于深入解析其生物学本质及品质形成机制。随着分子生物学的发展,不断丰富的组学技术使得从分子水平上阐述道地药材的系统发育和品质形成特征成为可能,尤其是基因组学的发展与应用也成为解密道地药材遗传成因的有力工具,分子标记、组学技术等已被广泛应用于道地药材遗传多样性、种群结构等微进化研究中。该文在总结道地药材“优形、优质”特征的基础上,对道地药材品质形成的微进化研究进行综述,并介绍了分子遗传标记、组学分析等分子生物学技术在解读道地药材形成机制上的应用,为更好地保护和利用中医药资源提供思路。Dao-di herbs are the treasure of Chinese materia medica and one of the characteristic research objects of traditional Chinese medicine(TCM).Probing into the microevolution of Dao-di herbs can help to reveal their biological essence and quality formation mechanisms.The progress in molecular biology and omics provides the possibility to elucidate the phylogenetic and quality forming characteristics of Dao-di herbs at the molecular level.In particular,genomics serves as a powerful tool to decipher the genetic origins of Dao-di herbs,and molecular markers have been widely used in the research on the genetic diversity and population structure of Dao-di herbs.Focusing on the excellent traits and quality of Dao-di herbs,this paper reviews the studies about the microevolution process of quality formation mechanisms of Dao-di herbs with the application of molecular markers and omics,aiming to underpin the protection and utilization of TCM resources.

关 键 词：道地药材 品质形成 微进化 分子标记 组学技术 

分 类 号：R282[医药卫生—中药学]