金钗石斛中1个新的异香木兰烷型倍半萜成分  

A new allo-aromadendrane sesquiterpene from Dendrobium nobile

作　　者：王俊豪 卢文旭 吴思佳 李剑 王峥涛[1] 徐红[1] WANG Jun-hao;LU Wen-xu;WU Si-jia;LI Jian;WANG Zheng-tao;XU Hong(the Ministry of Education Key Laboratory for Standardization of Chinese Medicines,the State Administration of Traditional Chinese Medicine Key Laboratory for New Resources and Quality Evaluation of Chinese Medicine,Shanghai R&D Center for Standardization of Chinese Medicines,Institute of Chinese Materia Medica,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Jinling Pharmaceutical Co.,Ltd.,Nanjing 210009,China)

机构地区：[1]上海中医药大学中药研究所,中药标准化教育部重点实验室,中药新资源与品质评价国家中医药管理局重点研究室,上海中药标准化研究中心,上海201203 [2]金陵药业股份有限公司,江苏南京210009

出　　处：《中国中药杂志》2023年第22期6088-6092,共5页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金面上项目(82173958);国家自然科学基金联合基金项目(U19A2009)。

摘　　要：研究金钗石斛Dendrobium nobile茎中非生物碱部分的化学成分。运用大孔吸附树脂、MCI、硅胶、反相C_(18)、Sephadex LH-20凝胶柱色谱、制备薄层色谱及制备型高效液相色谱等技术进行化合物的分离纯化,根据理化性质、波谱数据结合参考文献鉴定化合物结构。从金钗石斛茎中分离得到8个化合物,分别为soltorvum F(1)、对羟基苯丙酸(2)、香草酸(3)、对羟基苯甲酸(4)、N-反式桂皮酸酰对羟基苯乙胺(5)、(+)-(1R,2S,3R,4S,5R,6S,9R)-2,11,12-trihydroxypicrotoxane-3(15)-lactone(6)、dendronobilin H(7)、soltorvum E(8)。其中化合物1为新化合物,命名为soltorvum F,化合物8为首次从石斛属中分离得到。To study the chemical constituents in the non-alkaloid part of stems of Dendrobium nobile.The macroporous adsorption resin,MCI,silica gel,RP-C_(18),and Sephadex LH-20 gel,preparative thin layer chromatography,and preparative high-performance liquid chromatography(HPLC) were used to isolate and purify the compounds.The structures of the compound were determined according to the spectra data,physicochemical properties,and relevant references.A total of 8 compounds were isolated from D.nobile,which were soltorvum F(1),p-hydroxyphenylpropionic acid(2),vanillic acid(3),p-hydroxybenzoic acid(4),N-trans-cinnamic acid acyl-p-hydroxybenzene ethylamine(5),(+)-(1R,2S,3R,4S,5R,6S,9R)-2,11,12-trihydroxypicrotoxane-3(15)-lactone(6),dendronobilin H(7),soltorvum E(8).Compound 1 was a novel compound,named as soltorvum F.Compound 8 was isolated from Dendrobium species for the first time.

关 键 词：金钗石斛 化学成分 倍半萜 soltorvum F 

分 类 号：R284.1[医药卫生—中药学]