糖尿病血管并发症病理机制研究进展  

Research progress on pathological mechanism of vascular complications of diabetes

作　　者：赵蕙琛 扈艳雯 刘元涛 柴家超 马小莉[1] ZHAO Huichen;HU Yanwen;LIU Yuantao;CHAI Jiachao;MA Xiaoli(Department of Endocrinology,Qingdao Hospital,University of Health and Rehabilitation Sciences(Qingdao Municipal Hospital),Qingdao 260071,China;Department of Nutrition,Heze Municipal Hospital,Heze 274000,China;Department of Endocrinology,Qilu Hospital(Qingdao),Cheeloo College of Medicine,Shandong University,Qingdao 266035,Shandong,China;Department of Pediatric Orthopaedic,Qingdao Women and Children's Hospital,Qingdao University,Qingdao 266034,China)

机构地区：[1]康复大学青岛医院(青岛市市立医院)内分泌科,山东青岛260071 [2]菏泽市立医院营养科,山东菏泽274000 [3]山东大学齐鲁医院(青岛)内分泌科,山东青岛266035 [4]青岛市妇女儿童医院小儿骨科,山东青岛266034

出　　处：《青岛医药卫生》2023年第6期432-435,共4页Qingdao Medical Journal

基　　金：国际糖尿病交流与实践专项基金(Z-2017-26-2202-2)。

摘　　要：糖尿病(diabetesmellitus,DM)血管并发症是DM的主要并发症之一,涉及多种病因,其中,动脉粥样硬化(atherosclerosis,AS)是DM血管并发症的病理基础。本文基于AS讨论DM血管并发症的可能分子机制、我们总结了DM病理过程中影响AS形成的主要方面及其与慢性炎症的关系、同时讨论AS和DM相关的病理生理学特征,如氧化应激、蛋白激酶信号改变以及某些miR-NA和表观遗传修饰的作用。Vascular complications of diabetes mellitus are one of the main complications of diabetes,involving a variety of causes,among which atherosclerosis is the pathological basis of vascular complications of diabetes.In this paper,we discuss possible molecular mechanisms of vascular complications in diabetes based on atherosclerosis.We summarize the main aspects of diabetic pathology that influence the formation of atherosclerosis and its relationship with chronic inflammation.Pathophysiological features associated with atherosclerosis and diabetes,such as oxidative stress,altered protein kinase signaling,and the role of certain miRNA and epigenetic modifications,are also discussed.

关 键 词：糖尿病血管并发症 AS 炎症反应 氧化应激 表观遗传修饰 

分 类 号：R587.1[医药卫生—内分泌]