Application of artificial hibernation technology in acute brain injury  

作　　者：Xiaoni Wang Shulian Chen Xiaoyu Wang Zhen Song Ziqi Wang Xiaofei Niu Xiaochu Chen Xuyi Chen 

机构地区：[1]Graduate School of Tianjin University of Traditional Chinese Medicine,Tianjin,China [2]Characteristic Medical Center of People’s Armed Police Forces,Tianjin,China

出　　处：《Neural Regeneration Research》2024年第9期1940-1946,共7页中国神经再生研究（英文版）

基　　金：supported by the National Defense Science and Technology Outstanding Youth Science Fund Project,No.2021-JCJQ-ZQ-035;National Defense Innovation Special Zone Project,No.21-163-12-ZT-006-002-13;Key Program of the National Natural Science Foundation of China,No.11932013(all to XuC).

摘　　要：Controlling intracranial pressure,nerve cell regeneration,and microenvironment regulation are the key issues in reducing mortality and disability in acute brain injury.There is currently a lack of effective treatment methods.Hibernation has the characteristics of low temperature,low metabolism,and hibernation rhythm,as well as protective effects on the nervous,cardiovascular,and motor systems.Artificial hibernation technology is a new technology that can effectively treat acute brain injury by altering the body’s metabolism,lowering the body’s core temperature,and allowing the body to enter a state similar to hibernation.This review introduces artificial hibernation technology,including mild hypothermia treatment technology,central nervous system regulation technology,and artificial hibernation-inducer technology.Upon summarizing the relevant research on artificial hibernation technology in acute brain injury,the research results show that artificial hibernation technology has neuroprotective,anti-inflammatory,and oxidative stress-resistance effects,indicating that it has therapeutic significance in acute brain injury.Furthermore,artificial hibernation technology can alleviate the damage of ischemic stroke,traumatic brain injury,cerebral hemorrhage,cerebral infarction,and other diseases,providing new strategies for treating acute brain injury.However,artificial hibernation technology is currently in its infancy and has some complications,such as electrolyte imbalance and coagulation disorders,which limit its use.Further research is needed for its clinical application.

关 键 词：cute brain injury artificial hibernation HYPOTHERMIA low metabolism mild hypothermia 

分 类 号：R651.15[医药卫生—外科学]