基于线粒体能量代谢探讨“阴中求阳”法治疗慢性心力衰竭科学内涵  

Discussion on the Scientific Connotation of“Reinforcing Yang from Yin”Method in the Treatment of Chronic Heart Failure Based on Mitochondrial Energy Metabolism

作　　者：王菲 钟森杰 李欣春 廉坤 李琳 胡志希 WANG Fei;ZHONG Senjie;LI Xinchun;LIAN Kun;LI Lin;HU Zhixi(College of Traditional Chinese Medicine,Hunan University of Chinese Medicine,Changsha 410208,China)

机构地区：[1]湖南中医药大学中医学院,湖南长沙410208

出　　处：《中国中医药信息杂志》2024年第1期6-10,共5页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家自然科学基金(82274412);广东省重点领域研发项目(2020B1111100001);湖南省自然科学基金面上项目(2020JJ4062);湖南省学位与研究生教育改革研究项目(2020JGZX012)。

摘　　要：慢性心力衰竭是多种心血管疾病的终末阶段,线粒体能量代谢障碍在慢性心力衰竭的发展过程中发挥重要作用。中医学认为,心阴是心阳(气)的物质基础,心阳(气)亏虚是慢性心力衰竭的核心病机。本文基于线粒体能量代谢,从理论内涵、发病机制、病理生理联系及现代研究方面阐述“阴中求阳”法治疗慢性心力衰竭的科学内涵。深入微观层面论证运用“阴中求阳”法能有效改善心脏能量底物重构(阴),增强线粒体功能,提供能量支持(阳),为慢性心力衰竭的理论研究及临床防治提供参考。Chronic heart failure is the final stage of various cardiovascular diseases,and mitochondrial energy metabolism disorders have been proved to play an important role in the development of chronic heart failure.TCM believes that heart yin is the material basis of heart yang(qi),and deficiency of heart yang(qi)is the core pathogenesis of chronic heart failure.Based on mitochondrial energy metabolism,this article expounded the scientific connotation of“reinforcing yang from yin”in the treatment of chronic heart failure from the aspects of theoretical connotation,pathogenesis,pathophysiological relationship and modern research.In-depth study at the microscopic level demonstrated that the application of“reinforcing yang from yin”method can effectively improve the reconstruction of heart energy substrate(yin),enhance mitochondrial function,and finally provide energy support(yang),which could offer ideas for theoretical research and clinical prevention and treatment of chronic heart failure.

关 键 词：慢性心力衰竭 阴中求阳 线粒体能量代谢 

分 类 号：R259.416.1[医药卫生—中西医结合]