基于数据挖掘探讨中医治疗鼻衄用药规律  

Exploration on Medication Law of TCM Treatment for Epistaxis Based on Data Mining

作　　者：孙冬 何承菲 张润发 李惠真 杜娅 徐大为 杨程杰 张志玲[2] SUN Dong;HE Chengfei;ZHANG Runfa;LI Huizhen;DU Ya;XU Dawei;YANG Chengjie;ZHANG Zhiling(Fourth Clinical Medical College of Guangzhou University of Chinese Medicine,Shenzhen 518033,China;Shenzhen Traditional Chinese Medicine Hospital,Shenzhen 518033,China)

机构地区：[1]广州中医药大学第四临床医学院,广东深圳518033 [2]深圳市中医院,广东深圳518033

出　　处：《中国中医药图书情报杂志》2024年第1期97-102,共6页Chinese Journal of Library and Information Science for Traditional Chinese Medicine

摘　　要：目的 基于中医传承辅助平台2.5软件挖掘中医治疗鼻衄(鼻出血)的用药规律,探讨新方组合。方法 检索中国知识资源总库(CNKI)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(VIP)、中国生物医学文献数据库(CBM)建库至2022年12月1日中医治疗鼻衄的相关文献,录入中医传承辅助平台并建立处方数据库,运用频次统计、关联规则和复杂网络等方法分析处方药物使用频率、常用药对、组合规则,并探索新方。结果 筛选出有效方剂221首,涉及中药265味,其中使用频次≥20的常用中药33味,前3位分别为生地黄、黄芩、炙甘草。药性以寒、温为主,药味以苦、甘为主,归经主入肝经、肺经、心经、脾经、胃经。常用药物组合46个,核心组合36个,发现新方16首。生地黄为治疗鼻衄的核心药物,生地黄-黄芩、生地黄-当归、生地黄-黄芩-炙甘草、生地黄-牡丹皮-黄芩为常用药物组合。结论 中医治疗鼻衄秉清热凉血止血大法,佐以化瘀补血、补气摄血、滋阴降火,重视脏腑辨证精准治衄,并多用蜂蜜、炙甘草等甘味药取缓急、补中添益之功用,部分药物如黄芩、大蓟、栀子等用炒焦、炒炭以加强止血效力。Objective To explore the medication law of TCM in the treatment of epistaxis based on the TCM inheritance Auxiliary Platform 2.5 software;To explore new combinations of prescriptions.Methods Literature about TCM treatment for epistaxis was retrieved from CNKI,Wangfang Data,VIP and CBM from the establishment of the databases to December 1,2022.The data were input into the TCM inheritance Auxiliary Platform and a prescription database was established.Data mining functions such as frequency statistics,association rules and complex network were used to analyze the use frequency,commonly used drug pairs,and combination rules of drugs in the prescription for epistaxis,and new prescriptions were explored.Results Totally 221 effective prescriptions were screened out,involving 265 kinds of Chinese materia medica.Among them,33 kinds of commonly used Chinese materia medica were used more than or equal to 20,and the first three were:Rehmanniae Radix,Scutellariae Radix,and Glycyrrhizae Radix et Rhizoma Praeparata cum Melle.The properties were mainly cold and warm,tastes were mainly bitter and sweet,and meridians were mainly liver,lung,heart,spleen,and stomach meridians.There were 46 groups of commonly used combinations, 36 core combinations, and 16 new prescriptions were found. The analysis found that Rehmanniae Radix was the core drug for the treatment of epistaxis, and Rehmanniae Radix-Scutellariae Radix, Rehmanniae Radix-Angelicae Sinensis Radix, Rehmanniae Radix-Scutellariae Radix-Glycyrrhizae Radix et Rhizoma Praeparata cum Melle, Rehmanniae Radix-Moutan Cortex-Scutellariae Radix were commonly used drug combinations. Conclusion TCM treats epistaxis by clearing heat, cooling blood and stopping bleeding. It is assisted by removing blood stasis and supplementing blood, supplementing qi and absorbing blood, nourishing yin and reducing fire. They attach importance to the accurate treatment of epistaxis based on the syndrome differentiation of the zang-fu organs. They also use honey, Glycyrrhizae Radix et Rhizoma Praeparata cu

关 键 词：鼻衄 清热凉血 中医传承辅助平台 组方规律 数据挖掘 

分 类 号：R276.523[医药卫生—中医五官科学]