中医药基于“脑-肠轴”理论调节肠道菌群治疗小儿厌食症的研究进展  

Research Progress in Regulation of Intestinal Flora in Treatment of Pediatric Anorexia with Traditional Chinese Medicine Based on Theory of"Brain-Gut Axis"

作　　者：高汉媛 吴英[1] 杨江霞[1] 陈淑彦 岳晶晶 赵霞[1] GAO Hanyuan;WU Ying;YANG Jiangxia;CHEN Shuyan;YUE Jingjing;ZHAO Xia(Department Three of Acupuncture and Moxibustion,Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730050,China)

机构地区：[1]甘肃省中医院针灸三科,兰州730050

出　　处：《医学综述》2023年第23期5423-5427,共5页Medical Recapitulate

基　　金：国家自然科学基金(81960907)。

摘　　要：小儿厌食症是一种胃肠功能紊乱性疾病,其特征是患儿不思饮食、食而不化或偏食异物等,与中医脾运失健、胃纳失常诱发的“不食、不欲饮食、不思乳食”极为相似。肠道菌群与宿主共生,其组成、结构及生理功能的改变影响宿主健康。肠道菌群协助机体对饮食物的消化吸收作用与脾胃功能密切相关,肠道菌群失调可以导致及加重小儿厌食,同时肠道菌群作为“脑-肠轴”这一双向信息调节通路交互机制的中介,在人体健康和小儿厌食的防治过程中发挥重要作用。未来对其进行深入研究可为中医药通过调节肠道菌群防治小儿厌食症提供理论依据。Pediatric anorexia is a gastrointestinal dysfunction disease characterized by a lack of appetite,inability to digest food,or a preference for foreign objects.It is very similar to the"lack of food intake,lack of appetite,and lack of appetite for breast food"induced by spleen dysfunction and gastric motility disorders in traditional Chinese medicine.The gut microbiota coexists with the host,and changes in its composition,structure,and physiological function affect the host′s health.The assistance of gut microbiota in the digestion and absorption of food is closely related to the function of the spleen and stomach.Imbalance of gut microbiota can lead to and exacerbate anorexia in children.At the same time,gut microbiota plays an important role in human health and the prevention and treatment of anorexia in children as a mediator of the"brain-gut axis",a bidirectional information regulation pathway interaction mechanism.Further research on it in the future can provide theoretical basis for traditional Chinese medicine to prevent and treat anorexia in children by regulating gut microbiota.

关 键 词：小儿厌食症 中医药 肠道菌群 脑-肠轴 

分 类 号：R272.6[医药卫生—中医儿科学]