从肠道菌群调控探讨柴胡加龙骨牡蛎汤治疗热性惊厥的研究进展  

Research Progress of Chaihu-jia-Longgu-Muli-Decoction in Treatment of Febrile Convulsions from Perspective of Regulation of Intestinal Flora

作　　者：游隽婳 都修波[1,2] 常雅新 任艳桧 李洁[1,2] YOU Juanhua;DU Xiubo;CHANG Yaxin;REN Yanhui;LI Jie(Third Ward,Pediatrics Hospital,the First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450008,China;School of Pediatrics,Henan University of Chinese Medicine,Zhengzhou 450000,China)

机构地区：[1]河南中医药大学第一附属医院儿科医院三病区,郑州450008 [2]河南中医药大学儿科医学院,郑州450000

出　　处：《医学综述》2023年第23期5443-5447,共5页Medical Recapitulate

基　　金：河南省中医药科学研究专项课题(2019ZY2134)。

摘　　要：热性惊厥是儿科惊厥常见病的一种,在祖国医学中属于“惊风”范畴,反复性的惊厥发作或惊厥发作持续时间较长可导致患儿智力下降,甚至继发癫痫。肠道微生物群和脑-肠轴与许多代谢、免疫、神经系统的发病有关,菌群水平的高低不仅影响热性惊厥的发生,亦对其发展和预后产生重要作用。近年来,柴胡加龙骨牡蛎汤基于微生物角度对疾病产生的改善作用在控制惊厥发作、预防合并症发生等方面取得显著疗效,为治疗神经系统疾病和消化系统疾病提供了新的思路。Febrile convulsion is one of the most common pediatric convulsions,and belongs to the category of"convulsions"in Chinese medicine.Repeated convulsive seizures or prolonged duration of convulsive seizures can lead to intellectual decline and even secondary epilepsy.The intestinal microflora and brain-gut axis are related to many metabolic,immune,and neurological diseases.The level of microflora not only affects the occurrence of febrile convulsions,but also plays an important role in their development and prognosis.In recent years,Chaihu-jia-Longgu-Muli-decoction has achieved remarkable efficacy in controlling convulsions and preventing complications based on the microbial improvement of the disease,which provides new ideas for the treatment of neurological diseases and digestive diseases.

关 键 词：热性惊厥 柴胡加龙骨牡蛎汤 肠道菌群 脑-肠轴 

分 类 号：R720.597[医药卫生—急诊医学]