阿托伐他汀、前列地尔联合用药对糖尿病周围血管病变患者SOD、GSH-Px及血脂指标的影响  

Effects of Combination Drug of Atorvastatin and Alprostadil on SOD,GSH-Px and Lipid Indexes in Patients with Diabetic Peripheral Neuropa⁃thy

作　　者：王付颖 张琳 赵小君 WANG Fuying;ZHANG Lin;ZHAO Xiaojun(Department of Endocrinology,Lanling County People's Hospital,Linyi,Shandong Province,277700 China;Depart-ment of Cardiovascular Medicine,Lanling County People's Hospital,Linyi,Shandong Province,277700 China;De-partment of Respiratory Medicine,Lanling County People's Hospital,Linyi,Shandong Province,277700 China)

机构地区：[1]兰陵县人民医院内分泌科,山东临沂277700 [2]兰陵县人民医院心血管内科,山东临沂277700 [3]兰陵县人民医院呼吸内科,山东临沂277700

出　　处：《糖尿病新世界》2023年第20期20-23,共4页Diabetes New World Magazine

摘　　要：目的分析阿托伐他汀、前列地尔联合用药对糖尿病周围血管病变(diabetic peripheral neuropathy,DPN)患者超氧化物歧化酶(superoxide dismutase,SOD)、谷胱甘肽过氧化物酶(glutathione peroxidase,GSH-Px)及血脂指标的影响。方法选取2021年7月—2022年7月兰陵县人民医院收治的糖尿病周围血管病变患者80例作为研究对象,采取随机数表法将患者分为对照组(n=40)和观察组(n=40),对照组采用前列地尔治疗,观察组采用阿托伐他汀、前列地尔联合用药治疗。比较两组临床疗效以及氧化应激指标。结果观察组患者临床疗效优于对照组,差异有统计学意义(P<0.05)。治疗后,观察组SOD、GSH-Px高于对照组,MDA则低于对照组,差异有统计学意义(P<0.05)。结论在DPN患者的治疗中应用阿托伐他汀与前列地尔具备较好的临床效果,可有效改善患者氧化应激水平。Objective To analyze the effects of the combination drug of atorvastatin and alprostadil on superoxide dis-mutase(SOD),glutathione peroxidase(GSH-Px),and lipid indexes of diabetic peripheral neuropathy(DPN)patients.Methods A total of 80 patients with diabetic peripheral vascular disease admitted to Lanling County People's Hospi-tal from July 2021 to July 2022 were selected as the study objects,and the patients were divided into control group(n=40)and observation group(n=40)by random number table method.The control group was treated with alprostadil,and the observation group was treated with atorvastatin combined with alprostadil.The clinical efficacy and oxidative stress indexes of the two groups were compared.Results The clinical efficacy of the observation group was better than that of the control group,and the difference was statistically significant(P<0.05).After treatment,SOD and GSH-Px in observation group were higher than those in control group,MDA was lower than those in control group,and the dif-ferences were statistically significant(P<0.05).Conclusion The application of atorvastatin and alprostadil in the treat-ment of DPN patients has better clinical effects and can effectively improve the level of oxidative stress in patients.

关 键 词：阿托伐他汀 前列地尔 糖尿病周围血管病变 氧化应激反应 血脂指标 

分 类 号：R4[医药卫生—临床医学]