血清淀粉样蛋白A1水平预测急性心肌梗死的价值  

Serum amyloid A1 protein in the prediction of acute myocardial infarction

作　　者：闫朝晗 孟赫禹 陈艳秋 孟欣 王静茹 孟繁波[1,2] YAN Zhaohan;MENG Heyu;CHEN Yanqiu;MENG Xin;WANG Jingru;MENG Fanbo(Department of Cardiology,China-Japan Union Hospital of Jilin University,Changchun,Jilin 130033,China;不详)

机构地区：[1]吉林大学中日联谊医院心内科,吉林长春130033 [2]吉林省心血管病研究所,吉林长春130033

出　　处：《中国临床研究》2023年第12期1852-1856,共5页Chinese Journal of Clinical Research

基　　金：吉林省直卫生专项项目(2018SCZ008)。

摘　　要：目的探讨血清淀粉样蛋白A1(SAA1)对急性心肌梗死(AMI)的预测价值。方法选取吉林大学中日联谊医院2017年9月至2019年4月收治的139例AMI患者(AMI组)和146名非冠状动脉粥样硬化性心脏病患者(对照组)为研究对象。采取酶联免疫吸附法测定血浆SAA1水平,logistic回归分析AMI的独立影响因素,受试者工作特征(ROC)曲线分析SAA1诊断AMI的价值。结果AMI组SAA1水平低于对照组[2.62(2.08,3.21)ng/mL vs 5.18(3.24,8.27)ng/mL,Z=10.169,P<0.05]。SAA1水平降低与高密度脂蛋白胆固醇、白细胞计数、中性粒细胞/淋巴细胞存在相关性(P<0.05)。多因素logistic回归分析显示SAA1水平降低是AMI发生的独立危险因素(OR=0.468,95%CI:0.355~0.618,P<0.01)。ROC曲线提示SAA1诊断AMI的截断值为3.14 ng/mL,AUC为0.847,敏感性和特异性分别为76.1%和80.1%。结论AMI患者血浆中SAA1蛋白水平降低,SAA1水平或可作为AMI的独立预测指标。Objective To explore the predictive value of serum amyloid A1(SAA1)in acute myocardial infarction(AMI).Methods A total of 139 patients with AMI and 146 patients with non coronary atherosclerotic heart disease admitted to the China-Japan Union Hospital of Jilin University from September 2017 to April 2019 were selected as the research objects.Enzyme linked immunosorbent assay(ELISA)was used to determine the level of SAA1 in plasma.Logistic regression was used to analyze the independent influencing factors of AMI,and receiver operating characteristic(ROC)curve was used to analyze the value of SAA1 in the diagnosis of AMI.Results The level of SAA1 in the AMI group was lower than that in the control group[2.62(2.08,3.21)ng/mL vs 5.18(3.24,8.27)ng/mL,Z=10.169,P<0.05].The decrease in SAA1 level was correlated with high-density lipoprotein cholesterol,white blood cell count,and neutrophils/lymphocytes.Multivariate logistic regression analysis showed that the decreased SAA1 level was an independent risk factor for AMI occurrence.The ROC curve indicated that the cut-off value of SAA1 for diagnosing AMI was 3.14 ng/mL,and the AUC was 0.847,and the sensitivity and specificity were 76.1%and 80.1%,respectively.Conclusion The plasma levels of SAA1 decrease in AMI patients,and SAA1 levels may serve as an independent predictor of AMI.

关 键 词：急性心肌梗死 血清淀粉样蛋白A1 白细胞计数 高密度脂蛋白胆固醇 载脂蛋白A1 生物标志物 

分 类 号：R541[医药卫生—心血管疾病]