卵巢功能减退的血清抗体检测及卵泡功能复苏的临床治疗效果  

Serum antibody detection in patients with ovarian function decline and clinical treatment of follicular function recovery

作　　者：吕爱霞 王玲[1] 秦红平 王婷[1] 贾俊龙 折娅欢 莫少康 LYU Aixia;WANG Ling;QIN Hongping;WANG Ting;JIA Junong;SHE Yahuan;MO Shaokang(Gynecoogy and Obstetrics Reproductive Center,the 940th Hospita,of the Joint Logistics Support,Force of the People′s Liberation Army,Lanzhou 730050,Gansu,China)

机构地区：[1]中国人民解放军联勤保障部队第九四○医院妇产科生殖中心,兰州730050

出　　处：《中国性科学》2023年第12期64-68,共5页Chinese Journal of Human Sexuality

基　　金：甘肃省青年科技基金计划(20JR5RA592)。

摘　　要：目的探究血清抗体检测对卵巢功能减退治疗的意义,分析患者治疗前后卵泡功能复苏情况。方法选取2020年1月至2022年6月就诊于中国人民解放军联勤保障部队第九四○医院的120例卵巢功能减退患者作为观察组,同期同一医院的120例其他因素所致不孕患者作为对照组。检测两组抗卵巢抗体(AOAb)、抗心磷脂抗体(ACAb)水平,针对检测结果阳性的患者按照治疗方案不同分为治疗组与安慰剂组,各14例,分别给予地塞米松联合小剂量阿司匹林治疗与安慰剂治疗,对比患者卵泡功能复苏情况,并随访治疗效果。结果观察组AOAb、ACAb阳性共28例,占23.33%,高于对照组的4.17%,差异具有统计学意义(P<0.05)。治疗组与安慰剂组治疗前卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)水平差异无统计学意义(P>0.05);治疗后治疗组E2水平提高,FSH、LH水平降低,安慰剂组无明显变化,两组间比较差异具有统计学意义(P<0.05)。治疗组经过治疗后,采用B超监测发现均出现优势卵泡,但安慰剂组未见优势卵泡。治疗组中9例于治疗后2~3周来月经;5例月经恢复后2个月妊娠;2例治疗后月经规律,卵泡功能恢复正常。结论卵巢功能减退患者血清AOAb、ACAb阳性率高,给予免疫抑制剂与阿司匹林治疗,有利于促进卵泡功能复苏。Objective To explore the significance of serum antibody detection on ovarian function decline,and to analyze the recovery of patient follicle function before and after treatment.Methods A total of 120 cases with ovarian function decline admitted to the 940th Hospital of the Joint Logistics Support Force of the People′s Liberation Army from January 2020 to June 2022 were selected as observation group.In the same hospital,120 cases of infertility caused by other factors were selected as control group.The levels of anti-ovarian antibody(AOAb),anti-cardiolipin antibody(ACAb)in the two groups were detected.Patients with positive test results were divided into treatment group and placebo group according to different treatment plans,with 14 cases in each group.Dexamethasone combined with low-dose aspirin treatment and placebo treatment were given respectively.Follicle function recovery were compared and treatment effect was followed up.Results There were 28 cases of AOAb and ACAb positive in observation group,accounting for 23.33%,higher than 4.17%in the control group,and the difference was statistically significant(P<0.05).There were no statistical significance in the levels of follicle stimulating hormone(FSH),luteinizing hormone(LH)and estradiol(E2)levels between treatment group and placebo group before treatment(P>0.05).After treatment,E2 level increased in the treatment group,while FSH and LH decreased.There was no significant change in the placebo group,and the difference between the two groups was statistically significant(P>0.05).After treatment,14 patients in the treatment group were found to have dominant follicles by B-ultrasound monitoring,but no dominant follicles were found in the placebo groups.9 out of the 14 patients in the treatment group had menstruation 2 to 3 weeks after treatment,5 patients were pregnant 2 months after menstrual recovery,and 2 patients had regular menstruation and resumed normal follicular function after treatment.Conclusions The positive rate of serum AOAb and ACAb in patients w

关 键 词：卵巢功能减退 血清抗体 卵泡功能 阿司匹林 抗卵巢抗体 

分 类 号：R711[医药卫生—妇产科学]