噻托溴铵能倍乐?和噻托溴铵吸乐?在慢性阻塞性肺疾病患者中满意度和偏好度研究  

Satisfaction and preference of Tiotropium Respimat and Tiotropium Handihaler in patients with chronic obstructive pulmonary disease(COPD)

作　　者：时国朝[1] 林英翔[2] 郭禹标[3] 杨汀[4] 郑则广[5] 王玮[6] 王刚[7] 宋元林 陈荣昌[5,9] SHI Guochao;LIN Yingxiang;GUO Yubiao;YANG Ting;ZHENG Zeguang;WANG Wei;WANG Gang;SONG Yuanlin;CHEN Rongchang(Department of Respiratory and Critical Care Medicine,Ruijin Hospital,School of Medicine,Shanghai Jiaotong University,Shanghai 200025,China;Department of Respiratory and Critical Care Medicine,Beijing ChaoYang Hospital,Capital Medical University,Beijing 100020,China;Division of Pulmonary and Critical Care Medicine,the First Affiliated Hospital of Sun Yatsen University,Guangzhou,Guangdong 510080,China;Department of Pulmonary and Critical Care Medicine,Center of Respiratory Medicine,ChinaJapan Friendship Hospital,Beijing 100029,China;Department of Respiratory Medicine,The First Affiliated Hospital of Guangzhou Medical University,Guangzhou Institute of Respiratory Disease,Guangzhou,Guangdong 510120,China;Department of Respiratory Medicine,The First Hospital of China Medical University,Shenyang,Liaoning 110001,China;Department of Respiratory and Critical Care Medicine,West China Hospital of Sichuan University,Chengdu,Sichuan 610041,China;Department of Pulmonary Medicine,Zhongshan Hospital,Fudan University,Shanghai 200032,China;Department of Pulmonary and Critical Care Medicine,Shenzhen People’s Hospital,Shenzhen Institute of Respiratory Disease,Shenzhen,Guangdong 518001,China)

机构地区：[1]上海交通大学医学院附属瑞金医院呼吸与危重症医学科,上海200025 [2]首都医科大学附属北京朝阳医院呼吸与危重症医学科,北京100020 [3]中山大学附属第一医院呼吸与危重症医学科,广东广州510080 [4]中日友好医院呼吸与危重症医学科,北京100029 [5]广州医科大学附属第一医院呼吸内科广州呼吸疾病研究院,广东广州510120 [6]中国医科大学附属第一医院呼吸内科,辽宁沈阳110001 [7]四川大学华西医院呼吸与危重症医学科,四川成都610041 [8]复旦大学附属中山医院呼吸内科,上海200032 [9]深圳市人民医院呼吸与危重症医学科深圳市呼吸疾病研究所,广东深圳518001

出　　处：《临床肺科杂志》2024年第1期18-23,共6页Journal of Clinical Pulmonary Medicine

摘　　要：目的比较中国慢性阻塞性肺疾病(COPD)患者对噻托溴铵能倍乐■(软雾剂)与噻托溴铵吸乐■(干粉剂)吸入装置的满意度及偏好。方法一项多中心随机、开放、交叉研究。将中度至极重度COPD患者分为能倍乐■-吸乐■组与吸乐■-能倍乐■组,用患者满意度和偏好调查问卷(PASAPQ)比较两组治疗第8周时PASAPQ的性能评分、PASAPQ总评分、表达偏好的患者比例、PASAPQ的总体满意度评分及治疗后愿意继续使用的得分。结果共纳入71例COPD患者,其中能倍乐■-吸乐■组36例,吸乐■-能倍乐■组35例。基线资料显示两组性别、年龄,肺功能及慢性阻塞性肺疾病全球倡议(GOLD)分级,既往糖皮质激素/长效β2受体激动剂(ICS/LABA)的使用百分比等基线资料比较两组间无统计学差异。第8周时,PASAPQ性能评分、总评分和总体满意度评分在两组均无显著性差异。第8周时,35例(50.7%)患者偏好使用能倍乐■,26例(37.7%)患者偏好使用吸乐■,差异无统计学意义(P=0.249)。结论COPD患者对两种装置的满意度无明显差异,但患者掌握能倍乐■的操作方法后,有偏好使用能倍乐■的倾向性。Objective To compare the satisfaction and preference of Tiotropium Respimat(soft mist)with Tiotropium Handihaler(dry powder)in Chinese patients with chronic obstructive pulmonary disease(COPD).Meth-ods Patients with moderate to very severe COPD were classified into Respimat-Handihaler group and Handihaler-Respimat group.A randomized,multi-centre,open-label,two-way crossover study was carried out with an assessment by patient satisfaction and preference questionnaire(PASAPQ).The performance domain of the PASAPQ,PASAPQ total score,proportion of patients indicating preference,overall satisfaction question score from PASAPQ,and score on willingness to continue were assessed after treatment at week 8.Results A total of 71 patients were included.36 patients used Respimat first,then switched to Handihaler treatment.35 patients used Handihaler first,then switched to Respimat treatment.Baseline data showed no statistical significance between the two groups in gender,age,lung function,Global Initiative for Chronic Obstructive Lung Disease(GOLD)grade,or per-centage of previous use of inhaled corticosteroid/long-acting beta2-agonist(ICS/LABA).At week 8,the average PASAPQ performance domain,PASAPQ total score and PASAPQ overall satisfaction score of patients using Respimat were not significantly different from that of patients using Handihaler.At the end of treatment(week 8),35(50.7%)patients showed a preference for Respimat,while 26(37.7%)patients showed a preference to Handihaler,with no statistically significant difference(P=0.249).Conclusion There was no significant difference in the satisfaction of COPD patients with the two devices,however,there was a tendency of patients to prefer the use of Respimat over Handihaler once they had mastered the operation of Respimat.

关 键 词：慢性阻塞性肺疾病 噻托溴铵 吸入装置 患者满意度和偏好度 

分 类 号：R563.9[医药卫生—呼吸系统]