青藏高原相近海拔高度不同气候微环境的两地慢性高原病发病调查  

Investigation on the incidence of chronic altitude sickness in two places with different climatic microenvironments at similar altitudes on the Qinghai-Tibet Plateau

作　　者：柏雪烨紫 黄学文[2] 康龙丽[3] 李尚师[2] 王宇亮[4] 高文文[5] 刘慕源 杨宇 王授衔 李茂仕 胡博 徐鹏 BAIXUE Yezi;HUANG Xuewen;KANG Longli;LI Shangshi;WANG Yuliang;GAO Wenwen;LIU Muyuan;YANG Yu;WANG Shouxian;LI Maoshi;HU Bo;XU Peng(School of Medicine,Tibet University,Lhasa,Tibet 850011,China;Department of Mountain Disease,the General Hospital of Tibet Military Area Command,Lhasa,Tibet 850007,China;Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region/Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region,Xizang Minzu University,Xianyang,Shaanxi 712082,China;Department of Critical Care Medicine,the General Hospital of Tibet Military Area Command,Lhasa,Tibet 850007,China;Department of Gastroenterology,the General Hospital of Tibet Military Area Command,Lhasa,Tibet 850007,China)

机构地区：[1]西藏大学医学院,拉萨850011 [2]西藏军区总医院高山病科,西藏拉萨850007 [3]西藏民族大学高原病分子机制与干预研究重点实验室/高原环境与疾病相关基因研究重点实验室,陕西咸阳712082 [4]西藏军区总医院重症医学科,拉萨850007 [5]西藏军区总医院胃病科,拉萨850007

出　　处：《重庆医学》2023年第24期3713-3717,共5页Chongqing medicine

基　　金：国家自然科学基金项目(U20A20395)。

摘　　要：目的 通过调查青藏高原相近海拔高度但不同气候微环境的两地移居人员慢性高原病发病率及部分生理指标,了解除海拔高度以外高原不同气候微环境对移居人员慢性高原病发病的影响。方法 选择平均年龄、人员结构、平均移居高原时间、居住地海拔高度(甲地4 270 m、乙地4 295 m)相近,但气候微环境不同的2组移居人群[甲地(甲组)106人、乙地(乙组)为145人],进行慢性高原病发病情况调查。慢性高原病的诊断标准采用2004慢性高原病青海国际标准。比较2组慢性高原病发病率、高原指甲凹陷症发病率及指端氧饱和度、心率、血压等值。结果 甲组慢性高原病发病率为31.13%,乙组为10.34%,2组比较差异有统计学意义(P<0.01)。甲组指端氧饱和度为(87.99±3.33)%,乙组为(89.61±3.58)%,2组比较差异有统计学意义(P<0.01)。甲组高原指甲凹陷症发生率为30.19%,乙组为9.66%,2组比较差异有统计学意义(P<0.01)。甲组高血压发病率为2.80%,乙组为10.34%,2组比较差异有统计学意义(P<0.01)。甲组心率为(82.61±14.15)次/min,乙组为(75.79±12.34)次/min,2组比较差异有统计学意义(P<0.01)。甲组心动过速发病率为12.26%,乙组为3.45%,2组比较差异有统计学意义(P<0.01)。结论 除海拔高度因素外,恶劣气候微环境差异是移居人员慢性高原病发病的重要影响因素。Objective By investigating the incidence of chronic altitude sickness and some physiological indexes of migrants in the two places with similar altitudes but different climatic microenvironments on the Qinghai-Tibet Plateau,the effects of different climatic microenvironments on the incidence of chronic altitude sickness in migrants outside the altitude were lifted.Methods Two groups of migrants with similar average age,personnel structure,average migration time to the plateau,and altitude of residence(4 270 meters at place A peoples and 4 295 meters at place B) but different climate microenvironments were selected(106 peoples in group A and 145 peoples in group B) to investigate the incidence of chronic altitude sickness.The diagnostic criteria of chronic altitude sickness were based on the 2004 Qinghai standard.The incidence of chronic altitude sickness,the incidence of high altitude koilonychia,fingertip oxygen saturation,heart rate and blood pressure were compared between the two groups.Results The incidence of chronic altitude sickness was 31.13% in the group A and 10.34% in group B,he difference between the two groups was statistically significant(P<0.01).The finger tip oxygen saturation of group A was(87.99±3.33)%,and that of group B was(89.61±3.58)%.The difference between the two groups was statistically significant(P<0.01).The incidence of high altitude koilonychia was 30.19% in group A and 9.66% in group B,and the difference between the two groups was statistically significant(P<0.01).The incidence of hypertension in group A was 2.80%,and that in group B was 10.34%,he difference between the two groups was statistically significant(P<0.01).The heart rate of group A was(82.61±14.15)times/min,and that of group B was(75.79±12.34) times/min,the difference between the two group was statistically significant(P<0.01).The incidence of tachycardia was 12.26% in group A and 3.45% in group B,and the difference between the two groups was statistically significant(P<0.01).Conclusion In addition to the altitude fac

关 键 词：高原 慢性高原病 气候微环境 高原指甲凹陷症 

分 类 号：R594.3[医药卫生—内科学]