肠道菌群对慢性疲劳综合征中枢神经系统的调控机制  

Mechanism of Intestinal Flora Regulating the Central Nervous System of Patients with Chronic Fatigue Syndrome

作　　者：顾元嘉 谢芳芳 管翀 王桂茂[2] 成子己 张帅攀 郭光昕 姚斐[1,2] GU Yuanjia;XIE Fangfang;GUAN Chong;WANG Guimao;CHENG Ziji;ZHANG Shuaipan;GUO Guangxin;YAO Fei(School of Acupuncture-Moxibustion and Tuina,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Shanghai Municipal Hospital of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200071,China)

机构地区：[1]上海中医药大学针灸推拿学院,上海201203 [2]上海中医药大学附属市中医医院,上海200071

出　　处：《世界中医药》2023年第21期3109-3112,3117,共5页World Chinese Medicine

基　　金：国家自然科学基金面上项目(81774443)。

摘　　要：慢性疲劳综合征(CFS)是以长时间无法解释的疲劳、睡眠后精力无法自行恢复为主要特征的神经免疫疾病。肠道菌群作为调节中枢神经系统的关键因素,参与CFS的发生发展。为明确肠道菌群在CFS发病过程的作用机制。现基于微生物-肠-脑轴,分析影响CFS的肠道菌群及其代谢产物,探讨肠道菌群失调减弱内毒素耐受、破坏肠道屏障、改变肠道菌群代谢进而调控CFS中枢神经系统的内在机制。为进一步开展CFS肠道微生物研究提供参考,同时为CFS的防治提供新的临床思路。Chronic fatigue syndrome(CFS)is a neuroimmune disease characterized by unexplained fatigue for a long time and inability to recover energy after sleep.As a key factor regulating the central nervous system,intestinal flora participates in the occurrence and development of CFS.To clarify the mechanism of intestinal flora in the pathogenesis of CFS,this paper analyzed the intestinal flora and its metabolites affecting CFS based on the microorganism-gut-brain axis,and discussed the internal mechanism of intestinal flora imbalance in weakening endotoxin tolerance,destroying intestinal barrier,changing intestinal flora metabolism to regulate the central nervous system of CFS.The paper facilitates the further research on intestinal microorganisms of CFS patients and provide a new clinical idea for the prevention and treatment of CFS.

关 键 词：肠道菌群 慢性疲劳综合征 微生物-肠-脑轴 中枢神经系统 肠道屏障 内毒素耐受 神经炎症 

分 类 号：R259[医药卫生—中西医结合] R749.99[医药卫生—中医内科学]