白术对慢传输型便秘的药理作用及临床配伍应用研究现状  

Research Status on Pharmacological Effects and Clinical Compatibility of AtractylodisMacrocephalae Rhizoma on Slow-transit Constipation

作　　者：司香环 李东娜 李宏佳 徐天舒 SI Xianghuan;LI Dongna;LI Hongjia;XU Tianshu(Department of Traditional Chinese Medicine,Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine,Nanjing 210008,China;Department of Traditional Chinese Medicine,Nanjing Gulou Hospital,Nanjing 210008,China)

机构地区：[1]南京中医药大学鼓楼临床医学院中医科,南京210008 [2]南京鼓楼医院中医科,南京210008

出　　处：《世界中医药》2023年第21期3143-3148,共6页World Chinese Medicine

基　　金：国家自然科学基金面上项目(82273907);南京市卫生科技发展专项资金项目(ZKX21020)。

摘　　要：白术是经典的理气健脾中药,具有调和脾胃的作用,有健脾益气、燥湿利水、止汗、安胎的功效。现代药理学研究表明,白术中含有许多有效活性成分,例如挥发油、内酯等,具有抗炎、抗菌、保护神经等作用,可以有效改善肠道菌群及代谢产物,调节胃肠激素及神经递质等。目前,慢传输型便秘(STC)的发病率越来越高,严重者甚至危及生命,影响生命质量。研究表明白术治疗STC症状效果甚好,可有效改善STC患者的症状。现通过文献阅读,归纳总结白术及其活性成分在STC中的相关药理作用,对白术及其复方、经典方剂通过Cajal间质细胞(ICC)、肠神经递质、肠平滑肌、水通道蛋白(AQPs)等作用机制来治疗STC进行归纳总结,为临床规范化用药提供相应的参考作用。Atractylodis Macrocephalae Rhizoma is one of the classical herbs used in the management of qi and spleen,which has the effect of harmonizing the spleen and stomach,strengthening the spleen and benefiting qi,drying dampness and inducing diuresis,stopping sweating,and calming the fetus.Modern pharmacological studies have shown that Atractylodis Macrocephalae Rhizoma contains many effective active ingredients,such as volatile oils and lactones.It has anti-inflammatory,antibacterial,and neuroprotective effects and can effectively improve intestinal flora and metabolites and regulate gastrointestinal hormones and neurotransmitters.The current incidence of slow-transit constipation(STC)is getting higher,and the severe cases are even life-threatening,affecting people′s quality of life.Studies have shown that Atractylodis Macrocephalae Rhizoma has a good effect in treating STC and can effectively improve the symptoms of patients with STC.Through literature review,the relevant pharmacological effects of Atractylodis Macrocephalae Rhizoma and its active ingredients in STC were summarized,and the mechanisms of Atractylodis Macrocephalae Rhizoma and its compounds and classical formulas to treat STC through Cajal interstitial cells(ICC),intestinal neurotransmitters,intestinal smooth muscle,and water channel proteins(AQPs)were analyzed,so as to provide corresponding references for clinical standardization of medication.

关 键 词：白术 活性成分 慢传输型便秘 药理作用 肠道运动 神经递质 临床配伍 方剂 

分 类 号：R256[医药卫生—中医内科学] R442.2[医药卫生—中医学]