微生物-脑-肠轴与脑卒中后抑郁的研究进展  

Research Grogress of Microbiota-gut-brain Axis and Post-stroke Depression

作　　者：许慧 李恋秋 周鑫 刘辉[1] 叶海敏[2] XU Hui;LI Lianqiu;ZHOU Xin;LIU Hui;YE Haimin(Hunan University of Chinese Medicine,Changsha 410208,China;The Second Affiliated Hospital of Hunan University of Chinese Medicine,Changsha 410005,China)

机构地区：[1]湖南中医药大学,长沙410208 [2]湖南中医药大学第二附属医院,长沙410005

出　　处：《世界中医药》2023年第21期3149-3155,共7页World Chinese Medicine

基　　金：湖南省自然科学基金项目(2021JJ30519)——基于肠道微生物探讨电针“四关”穴对脑卒中后抑郁大鼠神经炎症的调控机制;湖南中医药大学校级科研基金项目(2020XJJJ056)。

摘　　要：脑卒中后抑郁(PSD)是指发生于脑卒中后,表现出脑卒中症状以外的一系列以情绪低落、兴趣缺失为主要特征的情感障碍综合征,常伴有躯体症状。微生物-脑-肠轴是指中枢神经系统和胃肠道之间持续的双向沟通,微生物-脑-肠轴之间的相互作用可能在脑卒中后抑郁的发病机制中发挥作用。现结合国内外的研究进展,就微生物-脑-肠轴在脑卒中后抑郁中的主要作用进行探讨,以期为脑卒中后抑郁的治疗提供新思路。Post-stroke depression(PSD)refers to a series of emotional disorder syndromes characterized by depression and lack of interest except for the symptoms of stroke,and it is often accompanied by physical symptoms.Microbiota-gut-brain axis refers to the continuous two-way communication between the central nervous system and the gastrointestinal tract.The interaction in the microbiota-gut-brain axis may play a role in the pathogenesis of PSD.Therefore,combined with the research progress in China and abroad,this paper discussed the main role of microbiota-gut-brain axis in PSD,so as to provide new ideas for the treatment of PSD.

关 键 词：微生物 脑卒中后抑郁 微生物-脑-肠轴 肠道菌群 益生菌 粪便移植 

分 类 号：R259[医药卫生—中西医结合]