不同病情严重程度子痫前期-子痫孕妇的凝血因子水平及其诊断价值  

Expression level and diagnostic value of coagulation factors in pregnant women with different severity of preeclampsia and eclampsia

作　　者：严璐曼 周海峰 王亭亭 YAN Luman;ZHOU Haifeng;WANG Tingting(Department of Obstetrics,Zhuji Maternal and Child Health Hospital,Zhuji 311800,China)

机构地区：[1]诸暨市妇幼保健院产科,浙江诸暨311800

出　　处：《健康研究》2023年第6期696-699,共4页Health Research

摘　　要：目的分析不同病情严重程度子痫前期-子痫孕妇的凝血因子水平,探讨凝血指标测定对疾病治疗及预后的价值。方法检测并比较轻度子痫前期(pre-eclampsia,PE)、重度PE、健康孕妇的凝血因子(PT、TT、APTT、FIB、D-D)水平;根据有无并发症对子痫前期-子痫孕妇进行分组,并比较两组凝血因子水平;ROC曲线分析凝血因子对重度子痫前期-子痫的诊断价值。结果各指标三组之间比较,差异有统计学意义(P<0.05);病情越严重,PT、APTT水平越低,TT、FIB、D-D水平越高,不同组别的同一指标比较差异有统计学意义(P<0.05)。并发症组PT、TT、APTT水平低于无并发症组,FIB、D-D水平高于无并发症组,差异均有统计学意义(P<0.05);D-D、PT、TT、APTT、FIB诊断重度PE的曲线下面积为0.896、0.904、0.756、0.855、0.848,其中TT诊断价值最低,差异有统计学意义(P<0.05)。结论妊娠子痫前期-子痫患者凝血指标异常程度随着病情的加重而升高,各凝血因子可作为预测病情严重程度的重要指标。Objective To investigate the levels of coagulation factors in pregnant women with varying severity of preeclampsia-eclampsia,and assess the significance of coagulation index determination for disease treatment and prognosis.Methods The coagulation levels of factors(PT,TT,APTT,FIB,D-D)in mild preeclampsia,severe preeclampsia,and healthy pregnant women were measured and compared.Pregnant women with preeclampsia/eclampsia were categorized according to complications,and their coagulation levels were compared between groups.The diagnostic value of coagulation factors in severe preeclampsia/eclampsia was analyzed by ROC curve.Results The statistically significant difference between the three groups was observed(P<0.05).As the severity of the disease increased,the levels of PT and APTT decreased whereas the levels of TT,FIB,and D-D increased.Additionally,the variation in the same index levels among different groups was also statistically significant(P<0.05).The levels of PT,TT and APTT were lower in the complication group compared to the non-complication group,whereas the levels of FIB and D-D were higher in the complication group with statistically significant differences(P<0.05).The area under the curve of D-D,PT,TT,APTT and FIB in the diagnosis of severe preeclampsia was 0.896,0.904,0.756,0.855 and 0.848,respectively.The diagnostic value of TT was found to be the lowest,and the difference was statistically significant(P<0.05).Conclusions The levels of coagulation indexes in patients with preeclampsia-eclampsia increase as the disease worsens.Each coagulation factor serves as a valuable indicator of disease severity.

关 键 词：子痫前期-子痫 凝血因子水平 诊断价值 

分 类 号：R714.244[医药卫生—妇产科学]