药食两用资源川党参重金属含量的测定及其健康风险评估  

Determination of Heavy Metal Content and Health Risk Assessment of Medicinal and Edible Codonopsis Tangshen

作　　者：赵春雪 李响 明鑫 木林 任艳 吴发明 ZHAO Chunxue;LI Xiang;MING Xin;MU Lin;REN Yan;WU Faming(School of Pharmacy,Southwest Minzu University,Chengdu 610000,China;Chongqing Wanzhou Institute for Food and Drug Control,Chongqing 404100,China;School of Pharmacy,Zunyi Medical University,Zunyi 563003,China)

机构地区：[1]西南民族大学药学院,四川成都610000 [2]重庆市万州食品药品检验所,重庆404100 [3]遵义医科大学药学院,贵州遵义563003

出　　处：《成都大学学报（自然科学版）》2023年第4期348-353,共6页Journal of Chengdu University（Natural Science Edition）

基　　金：西南民族大学国家级大学生创新创业训练计划项目(202210656043);贵州省科技厅科技支撑计划项目(82060687)。

摘　　要：通过对29批不同产地的川党参样品进行重金属含量测定,进而评估川党参健康风险.采用电感耦合等离子体质谱法测定川党参铬、砷、镉、铅和汞5种重金属元素含量,结合膳食暴露风险、非致癌健康风险和致癌健康风险对不同产地川党参药材质量进行评估.结果显示,川党参中的铬元素对成人存在一定的膳食暴露风险,其他4种重金属元素暂无膳食暴露风险;川党参的铅和铬对儿童均存在一定的膳食暴露风险,其他3种重金属元素暂无膳食暴露风险;对成人和儿童而言,不同产地的川党参均不存在非致癌风险和致癌风险.本研究的风险评估将为不同产地川党参质量评价提供一定参考.Heavy metal content from 29 different origins was determined to assess the health risk of Codonopsis tangshen.Inductively coupled plasma mass spectrometry(ICP-MS)was applied to measure the content of five heavy metal elements,Pb,Cr,As,Hg and Cd in Codonopsis tangshen.Combining dietary exposure risk,non-carcinogenic health risk,and carcinogenic health risk,the quality of Codonopsis tangshen from different origins was assessed.The result shows that the Cr has a certain dietary exposure risk for adults,while the other four metal elements have no dietary exposure risk.Pb and Cr pose certain dietary exposure risks to children whereas the other three metal elements pose no such risks.For adults and children,there is no non-carcinogenic or carcinogenic risk in Codonopsis tangshen from different origins.It can be concluded that the risk assessment in this paper is relevant to the quality assessment of Codonopsis tangshen from various origins.

关 键 词：川党参 重金属 电感耦合等离子体质谱法 健康风险评估 

分 类 号：R284.1[医药卫生—中药学]