2021—2022年某院耐多药结核分枝杆菌影响因素分析  

Analysis of Influencing Factors of Multidrug-resistant Mycobacterium Tuberculosis in a Hospital from 2021 to 2022

作　　者：常凤霞 纳元春 朋毛措 罗莉渊 CHANG Fengxia;NA Yuanchun;PENG Maocuo;LUO Liyuan(Department of Laboratory,Qinghai Fourth People's Hospital,Xining,Qinghai Province,810000 China)

机构地区：[1]青海省第四人民医院检验科,青海西宁810000

出　　处：《系统医学》2023年第18期73-75,79,共4页Systems Medicine

摘　　要：目的2021—2022年青海省第四人民医院耐多药结核分枝杆菌影响因素分析。方法选取2021年1月—2022年12月青海省第四人民医院诊治的结核分枝杆菌(mycobacterium tuberculosis,MTB)阳性肺结核患者200例,根据耐多药情况分为耐多药组(50例)和非耐多药组(150例),同时进行影响因素分析。结果耐多药组的低蛋白血症、糖尿病(diabetes mellitus,DM)、慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)、复治占比等明显高于非耐多药组,差异有统计学意义(P<0.05)。在200例人群中,多因素logistics回归分析显示低蛋白血症、DM、COPD、复治等都为导致耐多药MTB发生的独立危险因素(OR=3.155、2.681、4.446、3.588,P<0.05)。结论2021—2022年本院耐多药MTB的检出率比较高,低蛋白血症、DM、COPD、复治为独立危险因素,可为临床耐药结核的诊断治疗和个体化用药提供依据。Objective To analyze the influencing factors of multidrug-resistant Mycobacterium tuberculosis in Qinghai Fourth People's Hospital from 2021 to 2022.Methods 200 patients with Mycobacterium tuberculosis(MTB)-positive pulmonary tuberculosis diagnosed and treated in Qinghai Fourth People's Hospital were selected from January 2021 to December 2022,and were divided into multidrug-resistant group(50 cases)and non-multidrug-resistant group(150 cases)according to multidrug-resistant status,and the analysis of influencing factors was carried out at the same time.Results Hypoproteinemia,diabetes mellitus(DM),chronic obstructive pulmonary disease(COPD),and percentage of retreatment were significantly higher in the multidrug-resistant group compared with the non-multidrugresistant group,the difference was statistically significant(P<0.05).In a population of 200 cases,multifactorial logistic regression analysis showed that hypoproteinemia,DM,COPD,and relapse were independent risk factors for the development of multidrug-resistant MTB(OR=3.155,2.681,4.446,3.588,P<0.05).Conclusion The detection rate of multidrug-resistant MTB is relatively high in our hospital from 2021 to 2022,and hypoproteinemia,DM,COPD,and relapse to treatment are independent risk factors,which can provide a basis for the diagnosis and treatment of clinically drug-resistant tuberculosis and the individualization of medication.

关 键 词：耐多药结核分枝杆菌 结核病 影响因素 

分 类 号：R4[医药卫生—临床医学]