两种不同海洋生物材料对大鼠急性创面修复效果的研究  

Effect of two different marine biomaterials on acute wound repair in rats

作　　者：王蕾 吕康宁 李文军[1] 王凯 姜晓锐[3] 秦松[1] WANG Lei;LV Kang-ning;LI Wen-jun;WANG Kai;JIANG Xiao-rui;QIN Song(Yantai Institute of Coastal Zone Research,Yantai 264003,China;University of Chinese Academy of Sciences,Beijing 100049,China;Yantai Yuhuangding Hospital,Yantai 264001,China)

机构地区：[1]中国科学院烟台海岸带研究所,山东烟台264003 [2]中国科学院大学,北京100049 [3]烟台毓璜顶医院,山东烟台264001

出　　处：《海洋科学》2023年第10期87-93,共7页Marine Sciences

基　　金：山东省重点研发计划(重大科技创新工程)(2019JZZY011103)。

摘　　要：为研究来源于海洋的鱼类胶原蛋白和海藻酸盐对创面的修复效果,建立大鼠皮肤急性创面模型,对两种材料的功效进行探索。研究采用临床常用创面敷料使用方法,将两种材料植入创面处,采用细胞生物学、病理学等方法进行观察评价。结果显示,鱼胶原蛋白和海藻酸盐均具有良好的生物相容性和诱导创面修复能力,但在诱导血管长入、材料降解融合以及整体创面修复状态等方面,鱼类胶原蛋白要优于海藻酸盐。结果证明,两种不同的海洋生物材料均可以创造良好的伤口愈合环境,有效促进创面的修复。To investigate the wound healing effects of marine fish collagen and alginate,we established rat skin acute wound models and evaluated the efficacy of these two materials.We employed commonly used clinical wound dressing methods by implanting both materials into the wounds and observed and evaluated the outcomes using cell biology and pathology techniques.The results indicated that both fish collagen and alginate exhibited excellent biocompatibility and the ability to stimulate wound repair.However,fish collagen outperformed alginate in terms of promoting blood vessel ingrowth,material degradation and fusion,and overall wound healing.These findings demonstrate that both marine biomaterials create a conducive environment for wound healing and effectively facilitate the wound repair process.

关 键 词：创面修复 海藻酸盐 胶原蛋白 诱导 

分 类 号：Q819[生物学—生物工程]