淫羊藿苷对男性生殖系统的药理作用研究进展及文献可视化分析  

Pharmacological Effects of Icariin on Male Reproductive System:A Review andLiterature Visualization

作　　者：张静益 李俊君 方春燕 蒲诗云 张凤 杨薆黎 俞旭君[1,2] ZHANG Jingyi;LI Junjun;FANG Chunyan;PU Shiyun;ZHANG Feng;YANG Aili;YU Xujun(School of Clinical Medicine,Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China;TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province,Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China;The Second Clinical Medical College,Chengdu Fifth People's Hospital/Affiliated Fifth People's Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China)

机构地区：[1]成都中医药大学临床医学院,成都610075 [2]成都中医药大学附属医院代谢性疾病中医药调控四川省重点实验室,成都610075 [3]成都市第五人民医院/成都中医药大学附属第五人民医院第二临床医学院,成都611137

出　　处：《医药导报》2024年第1期96-105,共10页Herald of Medicine

基　　金：国家自然科学基金面上项目(81973647)。

摘　　要：淫羊藿苷是传统补益中草药淫羊藿的主要活性成分,属黄酮类化合物。现代研究表明,淫羊藿苷在男性生殖系统中作用广泛,具有调控细胞增殖与凋亡、抗氧化、促进睾酮生成、改善勃起功能、抑制前列腺癌细胞迁移与侵袭和调控细胞周期等多种药理活性,在男科及辅助生殖领域具有研究价值及应用前景。该文综述了淫羊藿苷在男性生殖系统的药理作用及其分子机制,并结合文献可视化分析探讨目前研究现状及热点,为淫羊藿苷在男性生殖健康领域的药用价值开发及临床应用提供参考。Icariin,which belongs to the class of flavonoids,is the main active ingredient of the traditional tonic Chinese herb Epimedii Folium.Modern studies have shown that icariin has a wide range of effects on the male reproductive system.It has various pharmacological activities such as regulating cell proliferation and apoptosis,antioxidants,promoting testosterone secretion,improving erectile function,inhibiting prostate cancer cell migration,invasion,and regulating cell cycle.It has research value and application prospects in the field of urology and assisted reproduction.Therefore,Icariin's pharmacological effects and molecular mechanisms on the male reproductive system are reviewed in this paper combined with literature visualization analysis.It is expected to provide a theoretical basis for the therapeutic value development and application of icariin in male reproductive health.

关 键 词：淫羊藿苷 男性生殖系统 信号通路 分子机制 文献计量学 可视化分析 

分 类 号：R285[医药卫生—中药学] R69[医药卫生—中医学]