血府逐瘀汤防治原发性肝癌TACE术后栓塞综合征的多中心临床研究  

Effect of Xuefu Zhuyu decoction in prevention and treatment of embolism syndrome after transcatheter arterial chemoembolization for primary liver cancer:A multicenter clinical study

作　　者：吴宇 李曦[1] 熊飞 保卫东 戴永洲 岳林君 刘源[1] WU Yu;LI Xi;XIONG Fei;BAO Weidong;DAI Yongzhou;YUE Linjun;LIU Yuan(The Affiliated Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610072,Sichuan,China)

机构地区：[1]成都中医药大学附属医院,四川成都610072

出　　处：《湖南中医杂志》2023年第11期4-7,共4页Hunan Journal of Traditional Chinese Medicine

基　　金：四川省中医药管理局科学技术研究专项(2020LC0090)。

摘　　要：目的:观察血府逐瘀汤对原发性肝癌经皮肝动脉化疗栓塞术(TACE)后栓塞综合征的影响。方法:将60例原发性肝癌患者随机分为治疗组与对照组,每组各30例。对照组于TACE术后第1天开始予以西医常规对症治疗,治疗组在对照组治疗基础上予以血府逐瘀汤治疗,2组疗程均为7 d。比较2组疼痛视觉模拟量表(VAS)评分、中医证候积分、体温、肝功能和临床疗效。结果:总有效率治疗组为83.3%(25/30),对照组为66.7%(20/30),2组比较,差异有统计学意义(P<0.05);2组VAS评分、中医证候积分、体温、肝功能治疗前后组内比较及治疗后同时间节点组间比较,差异均有统计学意义(P<0.05)。结论:血府逐瘀汤可有效改善TACE术引起的不良反应,缓解栓塞对患者的影响,增强治疗效果。Objective:To investigate the effect of Xuefu Zhuyu decoction on embolism syndrome after transcatheter arterial chemoembolization(TACE)for primary liver cancer.Methods:A total of 60 patients with primary liver cancer were randomly divided into treatment group and control group,with 30 patients in each group.The patients in the control group were given conventional Western medicine symptomatic treatment since day 1 after TACE,and those in the treatment group were given Xuefu Zhuyu decoction in addition to the treatment in the control group;the course of treatment was 7 days for both groups.The two groups were compared in terms of Visual Analogue Scale(VAS)score,TCM syndrome score,body temperature,liver function,and clinical outcome.Results:There was a significant difference in overall response rate between the treatment group and the control group[83.3%(25/30)vs 66.7%(20/30),P<0.05].After treatment,both groups had significant changes in VAS score,TCM syndrome score,body temperature,and liver function,and there were significant differences in these indices between the two groups after treatment(P<0.05).Conclusion:Xuefu Zhuyu decoction can effectively improve adverse reactions caused by TACE,alleviate the influence of embolism on patients,and enhance treatment efficacy.

关 键 词：原发性肝癌 TACE术 栓塞综合征 中西医结合治疗 血府逐瘀汤 

分 类 号：R273.57[医药卫生—中西医结合]