曾普华教授基于“癌毒驱动-态靶同调”辨治肿瘤恶液质  

Professor ZENG Puhua's treatment based on pattern identification for cancer cachexia based on"toxins activation and state-target simultaneous modulation"theory

作　　者：张长慧 李克雄 郜文辉[1] 曾普华[3] ZHANG Changhui;LI Kexiong;GAO Wenhui;ZENG Puhua(Hunan University of Chinese Medicine,Changsha,Hunan 410208,China;The Hospital of Hunan Academy of Chinese Medicine,Changsha,Hunan 410006,China;Hunan Academy of Chinese Medicine Cancer Institute,Changsha,Hunan 410006,China)

机构地区：[1]湖南中医药大学,湖南长沙410208 [2]湖南省中医药研究院附属医院,湖南长沙410006 [3]湖南省中医药研究院中医肿瘤研究所,湖南长沙410006

出　　处：《湖南中医药大学学报》2023年第12期2313-2317,共5页Journal of Hunan University of Chinese Medicine

基　　金：国家自然科学基金项目(82074425);湖南省自然科学基金青年基金项目(2023JJ40400);湖南省中医药科研计划项目(D2022010);湖南省中医药研究院院级课题(202115)。

摘　　要：总结曾普华教授从“癌毒驱动-态靶同调”辨治肿瘤恶液质的临证经验。曾普华教授认为癌毒驱动、因癌致虚、损正伤形是肿瘤恶液质的核心病机,尝试建立了肿瘤恶液质的态靶同调体系。肿瘤恶液质以虚态为主,癌毒是核心病靶,炎性细胞因子和白蛋白、血红蛋白等指标可为标靶,纳差、腹胀、消瘦等为症靶。临证治疗要紧扣核心病机,强调态靶结合,从宏观调正虚之态势,微观打癌毒之病靶,以扶正培本为基本治则,同时注重抗癌解毒、化瘀散结等以泻实祛滞,邪气衰则正气渐复。This paper has summarized the clinical experience of Professor ZENG Puhua in the treatment based on pattern identification of cancer cachexia based on"toxin activation and state-target simultaneous modulation"theory.The core pathogenesis is that cancer cachexia is induced by cancer toxins and deficiency is caused by cancer,in turn impairing healthy qi and damaging the body.An attempt has been made to establish a state-target simultaneous modulation system of cancer cachexia.Cancer cachexia mainly manifests as the deficiency state;cancer toxin is the core disease target;inflammatory cytokines,albumin,hemoglobin,and others can be the target;and poor appetite,abdominal distension,emaciation,etc.are the symptom target.In clinical treatment,Professor ZENG closely follows the core pathogenesis,emphasizes the combination of state and target,adjusts the state of healthy qi deficiency macroscopically,hits the target of cancer toxin microscopically,and sets reinforcing healthy qi to strengthen the body as the basic principle of treatment.Meanwhile,Professor ZENG focuses on anticancer and detoxification,and transforming stasis and resolving masses,so as to eliminate the excess and stagnation,so that the pathogenic qi could decline while the healthy qi could be gradually recovered.

关 键 词：肿瘤恶液质 癌毒 态靶医学 扶正培本 抗癌解毒 化瘀散结 曾普华 

分 类 号：R273[医药卫生—中西医结合]