血清中性粒细胞与淋巴细胞比值和CD64检测未足月胎膜早破并发亚临床绒毛膜羊膜炎的临床价值  

The clinical value of NLR and CD64 in preterm premature rupture of membranes with subclinical chorioamnitis

作　　者：杨秀莲[1] YANG Xiu-lian(Department of Obstetrics and Gynecology,Huizhou Third People's Hospital,Huizhou,Guangdong 516000,China)

机构地区：[1]惠州市第三人民医院妇产科,广东惠州516000

出　　处：《中国妇幼保健》2023年第24期4773-4776,共4页Maternal and Child Health Care of China

基　　金：广东省惠州市科技计划项目(180521171745886)。

摘　　要：目的分析联合检测血清中性粒细胞与淋巴细胞比值(neutrophil-to-lymphocyte ratio,NLR)、CD64变化水平对未足月胎膜早破(preterm premature rupture of membranes,PPROM)患者并发亚临床绒毛膜羊膜炎诊断的临床价值。方法选取2016年7月—2021年3月惠州市第三人民医院收治的90例PPROM患者作为病例组,同时选择相同孕周的50例未足月正常产检孕妇作为对照组,分析两组孕母血清中NLR、CD64变化水平,同时分析两者水平对PPROM并发亚临床绒毛膜羊膜炎诊断的灵敏度、特异度和阳性预测值。结果病例组孕母血清中NLR和CD64水平均高于对照组,差异有统计学意义(P<0.05),随着PPROM时间的延长,患者血清中NLR和CD64水平逐渐增高,差异有统计学意义(P<0.05);NLR、CD64两项指标联合检测在诊断PPROM并发亚临床绒毛膜羊膜炎的灵敏度、特异度、阳性预测值、阴性预测值分别为84.61%、80.00%、91.16%、66.67%;且随着亚临床绒毛膜羊膜炎的病情逐渐加重,患者血清中NLR和CD64水平逐渐增高,差异有统计学意义(P<0.05)。结论联合检测PPROM患者血清中NLR、CD64的变化水平,对于预测亚临床绒毛膜羊膜炎的发生具有较高的灵敏度、特异度及阳性预测值。Objective To analyze the clinical value of combined detection of serum NLR and CD64 in the diagnosis of subclinical chorioamnitis in preterm premature rupture of membranes.Methods Choose our hospital patients with premature rupture of membranes before term 90 cases as a group,at the same time,choose the same gestational weeks before term normal prenatal women 50 cases as control group,the analysis of two groups of motherhood NLR,CD64 changes in serum levels,at the same time analysis the two levels of premature rupture of membranes before term concurrent subclinical chorionic amniotic infection diagnostic sensitivity,specificity and positive predictive value.Results The levels of NLR and CD64 in serum of pregnant women in the case group were higher than those in the control group,the difference was statistically significant(P<0.05).With the prolonging of premature rupture time of preterm membranes,the levels of NLR and CD64 in serum of patients gradually increased,the difference was statistically significant(P<0.05).The sensitivity,specificity,positive predictive value and negative predictive value of NLR and CD64 in the diagnosis of preterm premature rupture of membranes complicated with subclinical chorioamnitis were 84.61%,80.00%,91.16%and 66.67%,respectively.And with the gradual aggravation of subclinical chorioamnitis,the levels of NLR and CD64 in serum of patients gradually increased,with statistical significance(P<0.05).Conclusion Combined detection of NLR and CD64 in serum of preterm premature rupture of membranes has high sensitivity,specificity and positive predictive value for predicting the occurrence of subclinical chorioamnitis.

关 键 词：中性粒细胞与淋巴细胞比值 CD64 未足月胎膜早破 亚临床绒毛膜羊膜炎 

分 类 号：R714.433[医药卫生—妇产科学]