黄芪化学成分抗纤维化作用及分子机制研究进展  

Research Progress on Antifibrotic Effect and Molecular Mechanisms of Chemical Components from Astragali Radix

作　　者：王佳俊 向世勰 谢治深 王潘 苗晋鑫[1] 张振强[1] 张效威 徐江雁[1] WANG Jiajun;XIANG Shixie;XIE Zhishen;WANG Pan;MIAO Jinxin;ZHANG Zhenqiang;ZHANG Xiaowei;XU Jiangyan(Henan University of Chinese Medicine,Zhengzhou 450046 Henan,China)

机构地区：[1]河南中医药大学,河南郑州450046

出　　处：《中药新药与临床药理》2023年第12期1799-1805,共7页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：国家重点研发计划项目(2020YFE0201800);河南省重点研发专项(221111520300);河南省重点研发与推广专项(科技攻关)(222102310647,232102310454);中国博士后科学基金项目(2020M682315);河南省高校科技创新团队支持计划项目(21IRTSTHN026)。

摘　　要：纤维化是指多类型的组织损伤,尤其是在慢性炎症反应性疾病过程中,组织修复平衡失调的终末结局。纤维化可发生于多种器官组织中,其持续进展可能导致器官功能障碍和衰竭,对人类健康构成了巨大的威胁。中药在预防和治疗纤维化方面有显著的治疗效果,具有多成分、多途径和多靶点的特点,已成为纤维化领域研究的热点。补气类中药黄芪为豆科植物蒙古黄芪或膜荚黄芪的根,具有益气升阳、生津养血、托毒排脓、敛疮生肌的功效。黄芪含有多糖类、皂苷类和黄酮类等化学成分,具有较好的抗炎、抗氧化等作用,可有效干预心脏、肾脏、肝脏和肺脏等多脏器组织的纤维化进程。该文综述了黄芪及其化学成分的抗纤维化药效作用及其机制,可为黄芪的进一步研究和应用提供思路和参考。Fibrosis refers to the final outcome of damage in multiple-type tissue and the imbalance of tissue repair especially in the process of chronic inflammatory response diseases.Fibrosis can occur in various organ tissues.Its continuous progression may lead to organ dysfunction and failure,which is a huge threat to human health.Traditional Chinese medicine has significant therapeutic effects in preventing and treating fibrosis.Due to its characteristics of multiple components,pathways,and targets,it has become a hot research topic in the field of fibrosis.Astragali Radix,a Chinese medicinal for supplementing qi,is the root of Astragalus membranaceus(Fisch.)Bge.var.mongholicus Hisao or Astragalus membranaceus(Fisch.)Bge.It has the effects of replenishing qi and elevating yang,generating fluid and nourishing blood,expelling toxin and draining pus,astringing sore and promoting granulation.It has found that Astragali Radix containss many chemical components such as polysaccharides,saponins,and flavonoids,which have good anti-inflammatory and antioxidant effects.Astragali Radix can effectively intervene in the fibrosis process of multiple organ tissues such as the heart,kidney,liver,and lung.Therefore,this article reviews the anti-fibrotic effects and mechanisms of Astragali Radix and its chemical components,hoping to provide ideas and references for the development and utilization of Astragali Radix.

关 键 词：黄芪 化学成分 抗纤维化 作用机制 

分 类 号：R285.5[医药卫生—中药学]