纳米纤维素基水凝胶在生物医学领域的研究进展  

Research Progress of Nanocellulose-based Hydrogels for Biomedical Applications

作　　者：李子江[1,2,3] 张洁 郭风军[1,2] 王滢 王娅萱[3] 刘华玉 张长峰[1,2] 司传领 LI Zijiang;ZHANG Jie;GUO Fengjun;WANG Ying;WANG Yaxuan;LIU Huayu;ZHANG Changfeng;SI Chuanling(Shandong Institute of Commerce and Technology,Ji’nan,Shandong Province,250103;National Engineering Research Center for Agricultural Products Logistics,Ji’nan,Shandong Province,250103;Tianjin Key Lab of Pulp&Paper,School of Light Industry Science and Engineering,Tianjin University of Science&Technology,Tianjin,300457)

机构地区：[1]山东商业职业技术学院,山东济南250103 [2]国家农产品现代物流工程技术研究中心,山东济南250103 [3]天津市制浆造纸重点实验室,天津科技大学轻工科学与工程学院,天津300457

出　　处：《中国造纸学报》2023年第4期116-125,共10页Transactions of China Pulp and Paper

基　　金：“十四五”国家重点研发计划项目(2021YFD2100505);山东省泰山学者特聘专家项目(TS20190956)。

摘　　要：纳米纤维素具有高比表面积(150~250 m^(2)/g)、大长径比、低密度(1.6 g/cm^(3))和优越的机械性能(弹性模量~150 GPa,高拉伸强度~7.5 GPa)等特性,在生物医学等领域有着广泛的应用。本文主要对近几年纳米纤维素基水凝胶的研究进展进行了归纳总结。首先介绍了纳米纤维素的制备方法,包括机械法、酸水解法、TEMPO(2,2,6,6⁃四甲基哌啶⁃1⁃氧化物自由基)氧化法和生物法;其次列举了制备纳米纤维素基水凝胶的常用交联方法,包括物理交联和化学交联;最后重点介绍了纳米纤维素基水凝胶在生物医学领域方面的应用,包括伤口敷料、组织工程和药物输送;此外,对纳米纤维素基水凝胶在生物医学领域的发展方向进行了展望。Nanocellulose has been widely used in biomedical and other fields because of its high specific surface area(150~250 m^(2)/g),large aspect ratio,low density(1.6 g/cm^(3))and excellent mechanical properties(elastic modulus~150 GPa,high tensile strength~7.5 GPa).This paper mainly summarized the research progress of nanocellulose-based hydrogels in recent years.Firstly,the preparation methods of nanocellulose were introduced,including mechanical,acid hydrolysis,TEMPO oxidation and biological methods.Secondly,the common cross-linking methods of nanocellulose-based hydrogels,including physical crosslinking and chemical crosslinking,were listed.Finally,the applications of nanocellulose-based hydrogels in biomedical fields,including wound dressings,tissue engineering and drug delivery,were introduced.In addition,the development direction of nanocellulose-based hydrogels in biomedical field was prospected.

关 键 词：纳米纤维素 水凝胶 制备 生物医学应用 

分 类 号：TS721[轻工技术与工程—制浆造纸工程] TQ352[化学工程]