电针联合泼尼松治疗Duchenne型肌营养不良的临床疗效观察  

Clinical efficacy of electroacupuncture combined with prednisone in the treatment of Duchenne muscular dystrophy

作　　者：欧梦迪 汪昌 喻绪恩 周洁 余亚运 沙从波 石永光 Ou Mengdi;Wang Chang;Yu Xuen;Zhou Jie;Yu Yayun;Sha Congbo;Shi Yongguang(Graduate School,Anhui University of Chinese Medicine,Hefei 230031,Anhui,China;The Affiliated Hospital of Institute of Neurology of Anhui University of Chinese Medicine,Hefei 230061,Anhui,China)

机构地区：[1]安徽中医药大学研究生院,安徽合肥230031 [2]安徽中医药大学神经病学研究所附属医院,安徽合肥230061

出　　处：《右江民族医学院学报》2023年第6期880-885,共6页Journal of Youjiang Medical University for Nationalities

基　　金：安徽省高校自然科学研究重点项目(KJ2021A0550)。

摘　　要：目的观察电针联合泼尼松治疗Duchenne型肌营养不良(Duchenne muscular dystrophy,DMD)患者的临床疗效。方法将入组的28例DMD患者随机分为治疗组(14例)和对照组(14例),治疗组为电针联合口服泼尼松的治疗,对照组则为单纯口服泼尼松治疗。治疗前后比较两组患者的4阶梯试验、10米步行时间和6 min步行距离前后的差异,观察近期疗效。结果两组患者经治疗后运动能力均有不同程度改善,4阶梯试验和6 min步行距离治疗前后有明显差异(P<0.01),治疗组10米步行时间治疗前后有差异(P<0.01),而对照组10米步行时间治疗前后无明显差异(P=0.290)。治疗后两组间比较,治疗组在4阶梯试验、10米步行时间和6 min步行距离的改善程度明显高于对照组(P<0.05)。治疗后治疗组NSAA积分高于对照组,差异有统计学意义(P<0.05)。结论电针联合泼尼松治疗DMD可以改善患者运动能力,疗效优于单纯口服泼尼松治疗。Objective To observe the clinical efficacy of electroacupuncture combined with prednisone in the treatment of Duchenne muscular dystrophy(DMD).Methods Twenty-eight patients with DMD were randomly divided into treatment group(14 cases)and control group(14 cases),with the treatment group treated with electroacupuncture combined with oral prednisone,and the control group treated with prednisone orally.Before and after treatment,the differences in the time of 4-step climb test and 10-meter walking and in the distance of 6-minute walking between the two groups were compared to observe the short-term efficacy.Results The motor ability of patients in two groups was improved to different degrees after treatment,and the differences in the time of the 4-step climb test and the 6-minute walking distance were significant before and after treatment(P<0.01).The 10-meter walking time of the treatment group was different before and after treatment(P<0.01),while the control group had no significant difference in distance before and after treatment(P=0.290).After treatment,the improvement in the 4-step climb test and 10-meter walking time and 6-minute walking distance in the treatment group was significantly higher than that in the control group(P<0.05).The NSAA scores in the treatment group after treatment was higher than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Electroacupuncture combined with prednisone in the treatment of DMD can improve the motor ability of patients,and its efficacy is better than that of oral prednisone treatment alone.

关 键 词：肌营养不良 杜氏 电针 泼尼松 

分 类 号：R685.9[医药卫生—骨科学] R746.2[医药卫生—外科学]