硬斑病患者健康相关生活质量的影响因素  

Influencing Factors Associated with Health-Related Quality of Life in Patient with Morphea

作　　者：龚诗蕊 吕小岩[1] GONG Shirui;LYU Xiaoyan(Department of Dermatology,West China Hospital,Sichuan University,Chengdu 610041,China)

机构地区：[1]四川大学华西医院皮肤科,四川成都610041

出　　处：《中国皮肤性病学杂志》2023年第12期1385-1388,共4页The Chinese Journal of Dermatovenereology

摘　　要：目的 了解硬斑病患者健康相关生活质量的影响因素。方法 对2021年4月-2022年4月于四川大学华西医院皮肤科门诊就诊的124例硬斑病患者进行横断面研究。收集汇总患者的人口学特征、临床表现、实验室检查以及疾病相关评分。使用U检验、H检验、相关分析及回归分析法,分析影响硬斑病患者生活质量的健康相关因素。结果 共纳入124例硬斑病患者,皮肤病生活质量指数(DLQI)的中位数为4.00(2.00, 8.00);与皮损累及其他部位、ANA阴性及不伴随或伴随其他症状的患者相比,皮损累及头面部、ANA阳性以及伴关节痛的患者DLQI分值较高,差异有统计学意义(P<0.05);华西心情指数(HEI)、局限性硬皮病皮肤评价工具(LoSCAT)以及改良局限性硬皮病严重指数(mLoSSI)与DLQI呈正相关(P<0.05);HEI每增加1分,DLQI增加0.283,ANA阳性患者DLQI分值较ANA阴性患者高4.407(P<0.05)。结论 硬斑病患者HEI高分及ANA阳性提示了较差的生活质量。Objective To evaluate the influencing factors of the health-related quality of life in patients with morphea.Methods A cross-sectional study was conducted on 124 patients with morphea who attended the outpatient clinic of the Department of Dermatology,West China Hospital of Sichuan University from April 2021 to April 2022.The data including demographic characteristics,clinical manifestations,laboratory tests,and disease-related scores were collected and recorded.U test,H test,correlation analysis,and regression analysis was used to analyze the factors that affect the health-related quality of life in patients with morphea.Results A total of 124 patients were recruited.The median of Dermatology Life Quality Index(DLQI)was 4.00(2.00,8.00).Compared with patients with lesions involving other sites,ANA negativity and without or accompanying other symptoms,DLQI scores were higher in patients with lesions involving the head and face,ANA positivity and with arthralgia,and the difference was statistically significant(P<0.05).Huaxi emotional index(HEI),localized scleroderma cutaneous assessment tool(LoSCAT),and modified localized scleroderma skin severity index(mLoSSI)were positively correlated with DLQI.DLQI increased by 0.283 for each 1-point increase in HEI,and DLQI was 4.407 higher in patients presenting with positive antinuclear antibodies than in those with negative antinuclear antibodies.Conclusion Higher HEI scores,and positive ANA in patients with morphea suggested a poorer quality of life.

关 键 词：硬斑病 局限性硬皮病 健康相关生活质量 生活质量 影响因素 

分 类 号：R593.25[医药卫生—内科学]