Treg、γδT和TRM细胞在斑块状银屑病免疫病理机制中的研究进展  

Research Progress of Treg,γδT and TRM Cell in Immunopathogenesis of Plaque Psoriasis

作　　者：甘奕传 张三泉 张锡宝 GAN Yichuan;ZHANG Sanquan;ZHANG Xibao(Guangzhou Institute of Dermatology,Institute of Dermatology,Guangzhou Medical University,Guangzhou 510095,China)

机构地区：[1]广州市皮肤病防治所,广州医科大学皮肤病研究所,广东广州510095

出　　处：《中国皮肤性病学杂志》2023年第11期1328-1333,共6页The Chinese Journal of Dermatovenereology

基　　金：广州市科技计划项目(202102080095)。

摘　　要：银屑病是一种遗传与环境共同作用诱发的免疫介导的慢性、复发性、炎症性、系统性疾病。斑块状银屑病的发病主要与T细胞及相关细胞因子以及表皮细胞介导的慢性炎症密切相关。近年来,许多研究显示调节性T细胞、γδT细胞和组织常驻记忆T细胞与斑块状银屑病的发生、发展及复发密切相关;T细胞亚群的相关研究进展不仅为阐明斑块状银屑病的发病机制提供依据,而且为靶向治疗提供新方向。本文就调节性T细胞、γδT细胞和组织常驻记忆T细胞在斑块状银屑病发病机制中的作用进行概述。Psoriasis is an immune-mediated chronic, recurrent, inflammatory, systemic disease induced by the joint effects of heredity and environment.Studies have confirmed that the pathogenesis of psoriasis is mainly related to chronic inflammation mediated by T cells,T-cell-related cytokines and epidermal cells. In recent years,numerous studies have shown that regulatory T cells, γδT cells and tissue resident memory T cells are closely related to the occurrence, development and relapse of psoriasis.These studying advances provide the basis for further elucidating the pathogenesis of psoriasis and a new direction for the targeted therapy. This article reviews the research progress towards general characteristics of the regulatory T cells,γδ T cells and tissues resident memory T cells and their role in plaque psoriasis.

关 键 词：银屑病 Treg细胞 ΓΔT细胞 组织常驻记忆T细胞 免疫病理机制 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]