器官芯片作为环境毒理学测试新策略的研究进展  

Advance of organ-on-a-chip technology in environmental toxicology assessment

作　　者：张天翊 胡承禹 杨圣 梁戈玉 Zhang Tianyi;Hu Chengyu;Yang Sheng;Liang Geyu(Key Laboratory of Environmental Medicine Engineering,Ministry of Education,School of Public Health,Southeast University,Nanjing 210009,China)

机构地区：[1]东南大学公共卫生学院,环境医学工程教育部重点实验室,江苏南京210009

出　　处：《兰州大学学报（医学版）》2023年第10期80-88,共9页Journal of Lanzhou University（Medical Sciences）

基　　金：国家自然科学基金资助项目(82173478);江苏省研究生科研与实践创新计划(KYCX23_0326)。

摘　　要：各种环境有害因素已经严重威胁到人类健康,快速、有效地对其评估至关重要。动物模型与体外二维细胞模型作为传统的环境毒理学测试平台,由于存在种属差异、缺乏细胞通信等不足,无法准确描述毒理学效应和预测人体内的实际反应。器官芯片技术可以高度复现体内复杂的微环境,并对环境有害因素产生真实的反应。器官芯片系统的可行性、可调整性和可靠性为环境毒理学测试提供了新的平台,深入研究将有望克服其面临的挑战,使其能够更精准地预测、评估环境有害因素的毒性作用,探索毒性机制,为建立毒理学测试新策略、推动人类健康事业发展提供新的技术平台。It is critical to evaluate the effects of environmental hazardous elements since they have already posed a great threat to human health.Due to species differences and a lack of cellular communication,the traditional environmental toxicology testing platforms,such as animal models and in vitro two-dimensional cell models are unable to effectively elaborate toxicity effects and reveal actual reactions in the human body.The viability,adaptability,and dependability of organ-on-a-chip technology make it possible to highly replicate the complex micro-environment in human body and react to environmental hazardous elements accurately,which provides new opportunities for environmental toxicology testing.Further research is expected to overcome the current challenges and make it more useful to evaluate the toxic effects of environmental harmful factors and explore the potential toxicity mechanisms,which would help to establish new toxicological testing strategies and protect human health.

关 键 词：器官芯片 环境毒理学 有害因素 

分 类 号：R12[医药卫生—环境卫生学]