Minimum inhibitory but maximum non-hemolytic concentration of plasma-treated catheters coated with L.tridentata and O.vulgare extracts  

作　　者：Francisco Javier ALONSO-MONTEMAYOR Miriam Desirée DÁVILA-MEDINA Alejandro ZUGASTI-CRUZ Rosa Idalia NARRO-CÉSPEDES María Guadalupe NEIRA-VELÁZQUEZ AidéSÁENZ-GALINDO Eduardo ALONSO-CAMPOS 

机构地区：[1]Autonomous University of Coahuila,Saltillo 25280,Mexico [2]Center for Research in Applied Chemistry,Saltillo 25294,Mexico [3]University of Monterrey,San Pedro Garza García 66238,Mexico

出　　处：《Plasma Science and Technology》2023年第12期83-96,共14页等离子体科学和技术（英文版）

基　　金：the grant(No.CVU 859503)given to the first author to pursue his doctorate in Materials Science and Technology at the Autonomous University of Coahuila(UAdeC);FONCYT-Fund Destined to Promote the Development of Science and Technology in the State of Coahuila(No.COAH-2020-C14-C058)。

摘　　要：Antibacterial extract-coated catheters are promising alternatives to their conventional counterparts,but their hemocompatibility and thermal stability must be studied.Nosocomial bacteria have developed resistance to conventional antibiotics.Herein,the minimum inhibitory but non-hemolytic concentration(MIC-NH)and the thermal stability of Larrea tridentata(L.tridentata)and Origanum vulgare(O.vulgare)extract-coated catheters were studied.Besides,plasma pretreatment was performed to enhance the extract adhesion.Briefly,the extract-coated catheters prevent Staphylococcus aureus colonization without causing hemolysis by using L.tridentata and O.vulgare extracts at MIC-NH(5000 and 2500μg ml~(-1),respectively).Moreover,it has been discovered that the extract coating and plasma treatment improved the thermal stability and the extract adhesion,respectively.Thus,this study provides evidence of alternative antibacterial but non-hemolytic extract-coated catheters.

关 键 词：antibacterial activity BIOCOMPATIBILITY blood-contact device cold plasma nosocomial bacteria 

分 类 号：R318.08[医药卫生—生物医学工程]