CT纹理分析在卵巢透明细胞癌与高级别浆液性囊腺癌鉴别诊断中的价值  

The Value of CT Texture Analysis in the Differential Diagnosis of Ovarian Clear Cell Carcinoma and High-grade Serous Cystadenocarcinoma

作　　者：邵景超 杜文壮 鞠文萍 时鹏飞 蒲如剑 王现亮[2] SHAO Jing-chao;DU Wen-zhuang;JU Wen-ping;SHI Peng-fei;PU Ru-jian;Wang Xian-liang(Department of Medical lmaging,Weifang Medical University,Weifang 261053,Shandong Province,China;Department of Radiology,Weifang People's Hospital,Weifang 261041,Shandong Province,China)

机构地区：[1]潍坊医学院医学影像学院,山东潍坊261053 [2]潍坊市人民医院放射科,山东潍坊261041

出　　处：《中国CT和MRI杂志》2023年第12期125-128,共4页Chinese Journal of CT and MRI

基　　金：山东省自然科学基金面上项目(ZR2020MH049)。

摘　　要：目的探讨CT纹理分析在鉴别卵巢透明细胞癌(ovarian clear cell carcinoma,OCCC)与高级别卵巢浆液性囊腺癌(high-grade ovarian serous cystadenocarcinoma,HGSC)中的价值。方法回顾性分析2020年1月-2022年4月在潍坊市人民医院住院治疗且经病理证实、临床资料完整的卵巢透明细胞癌患者23例及高级别浆液性囊腺癌患者35例。利用Image J软件测量并记录CT平扫期、动脉期、静脉期、延迟期四个时期的纹理参数,包括直方图参数(均值、标准差、偏度、峰度)及灰度共生矩阵参数(能量、对比、相关、逆差距、熵),比较两组间纹理参数的差异。采用两独立样本t检验或Mann-Whitney U检验对各参数统计分析,对差异有统计学意义的纹理参数进行ROC曲线分析,以判断其鉴别诊断效能。结果平扫期均值、标准差、偏度在两组间比较差异有统计学意义(P<0.05),且OCCC组均值、标准差小于HGSC组,OCCC组偏度大于HGSC组;峰度、能量、对比、相关、逆差距、熵差异无统计学意义(P>0.05)。动脉期均值、标准差在两组间比较差异有统计学意义(P<0.05),且OCCC组均值、标准差小于HGSC组;偏度、峰度、能量、对比、相关、逆差距、熵差异无统计学意义(P>0.05)。静脉期均值、偏度在两组间比较差异有统计学意义(P<0.05),且OCCC组均值小于HGSC组,OCCC组偏度大于HGSC组;标准差、峰度、能量、对比、相关、逆差距、熵差异无统计学意义(P>0.05)。延迟期均值、偏度在两组间比较差异有统计学意义(P<0.05),且OCCC组均值小于HGSC组,OCCC偏度大于HGSC组;标准差、峰度、能量、对比、相关、逆差距、熵差异无统计学意义(P>0.05)。其中诊断效能最佳者是平扫期均值,AUC=0.881(P<0.001),敏感度为65.22%,特异度为97.14%。结论CT纹理分析有助于鉴别卵巢透明细胞癌与高级别浆液性囊腺癌,可以为临床及影像诊断提供重要参考价值。Objective To explore the value of CT texture analysis in differentiating ovarian clear cell carcinoma(ovarian clear cell carcinoma,OCCC)from high-grade ovarian serous cystadenocarcinoma(high-grade ovarian serous cystadenocarcinoma,HGSC).Methods The clinical data of 23 patients with ovarian clear cell carcinoma and 35 patients with high-grade serous cystadenocarcinoma hospitalized in Weifang people's Hospital from January 2020 to April 2022 were analyzed retrospectively.The texture parameters of plain scan phase,arterial phase,venous phase and delayed phase of CT were measured and recorded by ImageJ software,including histogram parameters(mean,standard deviation,skewness,kurtosis)and gray co-occurrence matrix parameters(energy,contrast,correlation,inverse difference moment,entropy).The differences of texture parameters between the two groups were compared.Two independent samples t-test or Mann-WhitneyU test were used to analyze the parameters,and ROC curves were used to analyze the texture parameters with statistically significant differences,so as to judge the efficiency of differential diagnosis.Results The mean,standard deviation and skewness of the plain scan period were significantly different between the two groups(P<0.05),and the mean and standard deviation of the OCCC group were smaller than those of the HGSC group,and the skewness of the OCCC group was greater than that of the HGSC group;kurtosis,energy,There was no significant difference in contrast,correlation,inverse difference moment and entropy(P>0.05).The mean and standard deviation of the arterial phase were significantly different between the two groups(P<0.05),and the mean and standard deviation of the OCCC group were smaller than those of the HGSC group;skewness,kurtosis,energy,contrast,correlation,inverse difference moment,entropy differences No statistical significance(P>0.05).The mean and skewness of the venous phase were significantly different between the two groups(P<0.05),and the mean of the OCCC group was smaller than that of the HGSC gr

关 键 词：卵巢 透明细胞癌 高级别浆液性囊腺癌 计算机断层成像 纹理分析 

分 类 号：R445.3[医药卫生—影像医学与核医学]